The mechanisms of neurovascular coupling contribute to ensuring brain energy supply is
sufficient to meet demand. Despite significant research interest, the mechanisms underlying …

Intact, coordinated, and precisely regulated cerebrovascular responses are required for the
maintenance of cerebral metabolic homeostasis, adequate perfusion, oxygen delivery, and …

Cerebrovascular CO2 reactivity (CVR) is often considered a bioassay of cerebrovascular
endothelial function. We recently introduced a test of cerebral shear‐mediated dilatation …

Increases in arterial carbon dioxide tension (hypercapnia) elicit potent vasodilation of
cerebral arterioles. Recent studies have also reported vasodilation of the internal carotid …

Evidence for shear stress as a regulator of carotid artery dilation in response to increased
arterial CO2 was recently demonstrated in humans during sustained elevations in CO2 …

The cerebral vasculature manages oxygen delivery by adjusting arterial blood in‐flow in the
face of reductions in oxygen availability. Hypoxic cerebral vasodilatation, and the associated …

New Findings What is the topic of this review? Cerebrovascular reactivity to CO2, which is a
principal factor in determining ventilatory responses to CO2 through the role reactivity plays …

It is generally considered that regular exercise maintains brain health and reduces the risk of
cerebrovascular diseases such as stroke and dementia. Since the benefits of different …

The importance of nitric oxide (NO) in regulating cerebral blood flow (CBF) remains
unresolved, due in part to methodological approaches, which lack a comprehensive …

The global mean signal of resting-state fMRI (rs-fMRI) shows a characteristic spatiotemporal
pattern that is closely related to the pattern of vascular perfusion. Although being …