Pituitary adenomas are benign neoplasms originating in adenohypophysial cells. They
represent the most common neoplasm of the sellar region, comprising approximately 15% of …

Crooke's cell adenomas are a rare type of pituitary neoplasm. They produce
adrenocorticotropic hormone causing Cushing's disease or may be endocrinologically …

Cushing's disease is caused by functional corticotroph adenomas of the pituitary, mostly
noninvasive microadenomas. Classic Crooke's cells are nonneoplastic corticotrophs with …

The presence and patterns of keratins are critical in the classification of pituitary
neuroendocrine tumors. A large body of literature has included information about the …

Pituitary tumors are common and exhibit a wide spectrum of hormonal, proliferative and
invasive behaviors. Traditional classifications consider them malignant only when they …

Purpose We aimed to perform a retrospective analysis of a rare subtype of corticotroph
adenoma, Crooke's cell adenoma, to better understand its clinical features. Methods We …

Context: Although Crooke's changes in the pituitary corticotrophs were initially described in
1935, the prevalence in which the changes occur in patients with Cushing's syndrome (CS) …

The authors have shown previously that ubiquitin, a protein involved in the degradation of
short-lived and abnormal proteins, is present in several cytoplasmic inclusions of neurons …

Touch imprint cytology (TIC) and frozen section (FS) procedures are essential for
intraoperative pathological diagnosis (IPD). They are invaluable tools for therapeutic …

Electron microscopy, which has been instrumental in the characterization of normal pituitary
cell types, has also played a crucial role in the mirphologic classification pituitary adenomas …