Transcription termination in Escherichia coli is controlled by many factors. The sequence of
the DNA template, the structure of the transcript, and the actions of auxiliary proteins all play …

In bacteria, a fundamental level of gene regulation occurs by competitive association of
promoter-specificity factors called σs with RNA polymerase (RNAP). This σ cycle paradigm …

Escherichia coli rho-independent transcription terminators are characterized by an RNA
structure having a G+ C-rich stem-loop followed by a series of uridine residues, but they can …

Passage of E. coli RNA polymerase through an intrinsic transcription terminator, which
encodes an RNA hairpin followed by a stretch of uridine residues, results in quick …

By thinking about the chemical and physical mechanisms that are involved in the stepwise
elongation of RNA transcripts, we can begin to understand the way that these mechanisms …

Escherichia coli RNA polymerase can terminate transcription efficiently at rho-independent
terminators in a purified transcription system in the absence of accessory factors. This …

Schafer et al.(Nature 352: 444–448 (1991)) devised the tethered particle motion (TPM)
method to detect directly the movement of single, isolated molecules of a processive nucleic …

The structure of E. coli core RNA polymerase(RNAP) has been determined to-23 A
resolution by threedimensional reconstruction from electron micrographs of flattened helical …

The process of RNA chain initiation by RNA polymerases plays a central role in the
regulation of transcription. In this complex phase of transcription, short oligomers are …

This paper describes the binding interactions of Escherichia coli transcription factors σ 70
and NusA with core RNA polymerase, both free in solution and as a part of the functional …