Insulin-like growth factor receptor signaling in tumorigenesis and drug resistance: a challenge for cancer therapy
H Hua, Q Kong, J Yin, J Zhang, Y Jiang - Journal of hematology & …, 2020 - Springer
Insulin-like growth factors (IGFs) play important roles in mammalian growth, development,
aging, and diseases. Aberrant IGFs signaling may lead to malignant transformation and …
aging, and diseases. Aberrant IGFs signaling may lead to malignant transformation and …
Targeting DNA double-strand break repair pathways to improve radiotherapy response
M Toulany - Genes, 2019 - mdpi.com
More than half of cancer patients receive radiotherapy as a part of their cancer treatment.
DNA double-strand breaks (DSBs) are considered as the most lethal form of DNA damage …
DNA double-strand breaks (DSBs) are considered as the most lethal form of DNA damage …
The IGF/insulin-IGFBP axis in corneal development, wound healing, and disease
The insulin-like growth factor (IGF) family plays key roles in growth and development. In the
cornea, IGF family members have been implicated in proliferation, differentiation, and …
cornea, IGF family members have been implicated in proliferation, differentiation, and …
[HTML][HTML] Post-translational modifications of PCNA in control of DNA synthesis and DNA damage tolerance-the implications in carcinogenesis
S Zhang, T Zhou, Z Wang, F Yi, C Li… - … Journal of Biological …, 2021 - ncbi.nlm.nih.gov
The faithful DNA replication is a critical event for cell survival and inheritance. However,
exogenous or endogenous sources of damage challenge the accurate synthesis of DNA …
exogenous or endogenous sources of damage challenge the accurate synthesis of DNA …
Targeting AKT/PKB to improve treatment outcomes for solid tumors
The serine/threonine kinase AKT, also known as protein kinase B (PKB), is the major
substrate to phosphoinositide 3-kinase (PI3K) and consists of three paralogs: AKT1 (PKBα) …
substrate to phosphoinositide 3-kinase (PI3K) and consists of three paralogs: AKT1 (PKBα) …
Maneuvers on PCNA rings during DNA replication and repair
D Slade - Genes, 2018 - mdpi.com
DNA replication and repair are essential cellular processes that ensure genome duplication
and safeguard the genome from deleterious mutations. Both processes utilize an …
and safeguard the genome from deleterious mutations. Both processes utilize an …
[HTML][HTML] Nuclear localization and actions of the insulin-like growth factor 1 (IGF-1) system components: Transcriptional regulation and DNA damage response
E Poreba, J Durzynska - Mutation Research/Reviews in Mutation Research, 2020 - Elsevier
Insulin-like growth factor (IGF) system stimulates growth, proliferation, and regulates
differentiation of cells in a tissue-specific manner. It is composed of two insulin-like growth …
differentiation of cells in a tissue-specific manner. It is composed of two insulin-like growth …
IGF-1R targeting in cancer–does sub-cellular localization matter?
The insulin-like growth factor receptor (IGF-1R) was among the most intensively pursued
kinase targets in oncology. However, even after a slew of small-molecule and antibody …
kinase targets in oncology. However, even after a slew of small-molecule and antibody …
Effects and potential mechanisms of IGF1/IGF1R in the liver fibrosis: A review
R Gui, W Li, Z Li, H Wang, Y Wu, W Jiao, G Zhao… - International Journal of …, 2023 - Elsevier
Liver fibrosis is a wound-healing response due to persistent liver damage and it may
progress to cirrhosis and even liver cancer if no intervention is given. In the current …
progress to cirrhosis and even liver cancer if no intervention is given. In the current …
Nuclear IGF1R interacts with regulatory regions of chromatin to promote RNA polymerase II recruitment and gene expression associated with advanced tumor stage
T Aleksic, N Gray, X Wu, G Rieunier, E Osher, J Mills… - Cancer research, 2018 - AACR
Internalization of ligand-activated type I IGF receptor (IGF1R) is followed by recycling to the
plasma membrane, degradation or nuclear translocation. Nuclear IGF1R reportedly …
plasma membrane, degradation or nuclear translocation. Nuclear IGF1R reportedly …