Somatosensory afferents are traditionally classified by soma size, myelination, and their
response specificity to external and internal stimuli. Here, we propose the functional …

The somatosensory system processes diverse types of information including mechanical,
thermal, and chemical signals. It has an essential role in sensory perception and body …

The nucleus accumbens (NAc) plays an important role in motivation and reward processing.
Recent studies suggest that different NAc subnuclei differentially contribute to reward …

Our recent study demonstrated the critical role of the mesolimbic dopamine (DA) circuit and
its brain-derived neurotropic factor (BDNF) signaling in mediating neuropathic pain. The …

The spino-ponto-amygdaloid pathway is a major ascending circuit relaying nociceptive
information from the spinal cord to the brain. Potentiation of excitatory synaptic transmission …

The presence of central neuropathic pain in Parkinson's disease suggests that the brain
circuits that allow us to process pain could be dysfunctional in the disorder. However, there …

Depression symptoms are often found in patients suffering from chronic pain, a
phenomenon that is yet to be understood mechanistically. Here, we systematically …

Appropriate processing of reward and aversive information is essential for survival. Although
a critical role of serotonergic neurons in the dorsal raphe nucleus (DRN) in reward …

Damage to the nervous system can lead to functional impairment, including sensory and
motor functions. Importantly, neuropathic pain (NPP) can be induced after nerve injury …

Emerging evidence suggests that the mesolimbic dopaminergic network plays a role in the
modulation of pain. As chronic pain conditions are associated with hypodopaminergic tone …