Role of oxidative stress in the pathogenesis of non-alcoholic fatty liver disease: implications for prevention and therapy

JC Arroyave-Ospina, Z Wu, Y Geng, H Moshage - Antioxidants, 2021 - mdpi.com
Oxidative stress (OxS) is considered a major factor in the pathophysiology of inflammatory
chronic liver diseases, including non-alcoholic liver disease (NAFLD). Chronic impairment of …

The Role of l-Carnitine in Mitochondria, Prevention of Metabolic Inflexibility and Disease Initiation

MA Virmani, M Cirulli - International journal of molecular sciences, 2022 - mdpi.com
Mitochondria control cellular fate by various mechanisms and are key drivers of cellular
metabolism. Although the main function of mitochondria is energy production, they are also …

[HTML][HTML] l-carnitine: Nutrition, pathology, and health benefits

AH Alhasaniah - Saudi Journal of Biological Sciences, 2023 - Elsevier
Carnitine is a medically needful nutrient that contributes in the production of energy and the
metabolism of fatty acids. Bioavailability is higher in vegetarians than in people who eat …

[HTML][HTML] Silica nanoparticles aggravated the metabolic associated fatty liver disease through disturbed amino acid and lipid metabolisms-mediated oxidative stress

A Abulikemu, X Zhao, H Xu, Y Li, R Ma, Q Yao, J Wang… - Redox Biology, 2023 - Elsevier
The metabolic associated fatty liver disease (MAFLD) is a public health challenge, leading to
a global increase in chronic liver disease. The respiratory exposure of silica nanoparticles …

Role of carnitine in non-alcoholic fatty liver disease and other related diseases: an update

N Li, H Zhao - Frontiers in medicine, 2021 - frontiersin.org
Carnitine is an amino acid-derived substance that coordinates a wide range of biological
processes. Such functions include transport of long-chain fatty acids from the cytoplasm to …

Dietary supplementation with casein/cyanidin-3-O-glucoside nanoparticles alters the gut microbiota in high-fat fed C57BL/6 mice

Q Lyu, H Deng, S Wang, H El-Seedi, H Cao, L Chen… - Food Chemistry, 2023 - Elsevier
This study aims to investigate the dietary intervention effect of casein/cyanidin-3-O-glucoside
nanoparticles (Cs-C3G) on high-fat-diet (HFD) induced gut microbiota disorders. In HFD-fed …

Lessons on drug development: a literature review of challenges faced in nonalcoholic fatty liver disease (NAFLD) clinical trials

JYS Chen, D Chua, CO Lim, WX Ho… - International Journal of …, 2022 - mdpi.com
NAFLD is the most common chronic liver disease worldwide, occurring in both obese and
lean patients. It can lead to life-threatening liver diseases and nonhepatic complications …

Changes in lipidomics, metabolomics, and the gut microbiota in CDAA-induced NAFLD mice after polyene phosphatidylcholine treatment

J Zhang, X Zang, J Lv, Y Zhang, Z Lv, M Yu - International Journal of …, 2023 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in most
parts of the world. Although there is no first-line drug approved for the treatment of NAFLD …

The effects of L-carnitine supplementation on inflammatory and anti-inflammatory markers in adults: a systematic review and dose–response meta-analysis

S Rastgoo, ST Fateh, M Nikbaf-Shandiz, N Rasaei… - …, 2023 - Springer
L-carnitine supplementation may be beneficial in improving inflammatory conditions and
reducing the level of inflammatory cytokines. Therefore, according to the finding of …

[HTML][HTML] A novel chicken model of fatty liver disease induced by high cholesterol and low choline diets

CW Lin, TW Huang, YJ Peng, YY Lin, HJ Mersmann… - Poultry Science, 2021 - Elsevier
Fatty liver diseases, common metabolic diseases in chickens, can lead to a decrease in egg
production and sudden death of chickens. To solve problems caused by the diseases …