The mitochondrial electron transport chain utilizes a series of electron transfer reactions to
generate cellular ATP through oxidative phosphorylation. A consequence of electron …

Animals display substantial inter-species variation in the rate of embryonic development
despite a broad conservation of the overall sequence of developmental events. Differences …

Context.—Needle biopsy of diseased tissue is an essential diagnostic tool that is becoming
even more important as precision medicine develops. However, the capability of this …

Importance The pathophysiology of exercise intolerance in patients with heart failure with
preserved ejection fraction (HFpEF) remains incompletely understood. Multiple lines of …

Objectives: The aim of this study was to examine skeletal muscle mitochondria content,
oxidative capacity, and the expression of key mitochondrial dynamics proteins in patients …

Isolated mitochondria are useful to study fundamental processes including mitochondrial
respiration, metabolic activity, protein import, membrane fusion, protein complex assembly …

Blood based bioenergetic profiling strategies are emerging as potential reporters of systemic
mitochondrial function; however, the extent to which these measures reflect the bioenergetic …

Working with isolated mitochondria is the gold standard approach to investigate the function
of the electron transport chain in tissues, free from the influence of other cellular factors. In …

Blood‐based bioenergetic profiling provides a minimally invasive assessment of
mitochondrial health shown to be related to key features of aging. Previous studies show …

Mitochondrial reactive oxygen species (ROS) are essential regulators of cellular signaling,
metabolism and epigenetics underlying the pathophysiology of numerous diseases. Despite …