[HTML][HTML] Mitochondrial electron transport chain: Oxidative phosphorylation, oxidant production, and methods of measurement
D Nolfi-Donegan, A Braganza, S Shiva - Redox biology, 2020 - Elsevier
The mitochondrial electron transport chain utilizes a series of electron transfer reactions to
generate cellular ATP through oxidative phosphorylation. A consequence of electron …
generate cellular ATP through oxidative phosphorylation. A consequence of electron …
Metabolic regulation of species-specific developmental rates
M Diaz-Cuadros, TP Miettinen, OS Skinner, D Sheedy… - Nature, 2023 - nature.com
Animals display substantial inter-species variation in the rate of embryonic development
despite a broad conservation of the overall sequence of developmental events. Differences …
despite a broad conservation of the overall sequence of developmental events. Differences …
Needle biopsy adequacy in the era of precision medicine and value-based health care
KPH Pritzker, HJ Nieminen - Archives of pathology & …, 2019 - meridian.allenpress.com
Context.—Needle biopsy of diseased tissue is an essential diagnostic tool that is becoming
even more important as precision medicine develops. However, the capability of this …
even more important as precision medicine develops. However, the capability of this …
Skeletal muscle mitochondrial respiration and exercise intolerance in patients with heart failure with preserved ejection fraction
L Scandalis, DW Kitzman, BJ Nicklas, M Lyles… - JAMA …, 2023 - jamanetwork.com
Importance The pathophysiology of exercise intolerance in patients with heart failure with
preserved ejection fraction (HFpEF) remains incompletely understood. Multiple lines of …
preserved ejection fraction (HFpEF) remains incompletely understood. Multiple lines of …
Skeletal muscle mitochondrial content, oxidative capacity, and Mfn2 expression are reduced in older patients with heart failure and preserved ejection fraction and are …
AJA Molina, MS Bharadwaj, C Van Horn, BJ Nicklas… - JACC: Heart Failure, 2016 - jacc.org
Objectives: The aim of this study was to examine skeletal muscle mitochondria content,
oxidative capacity, and the expression of key mitochondrial dynamics proteins in patients …
oxidative capacity, and the expression of key mitochondrial dynamics proteins in patients …
Isolation of mitochondria from cells and tissues
Isolated mitochondria are useful to study fundamental processes including mitochondrial
respiration, metabolic activity, protein import, membrane fusion, protein complex assembly …
respiration, metabolic activity, protein import, membrane fusion, protein complex assembly …
[HTML][HTML] Blood cell respirometry is associated with skeletal and cardiac muscle bioenergetics: Implications for a minimally invasive biomarker of mitochondrial health
Blood based bioenergetic profiling strategies are emerging as potential reporters of systemic
mitochondrial function; however, the extent to which these measures reflect the bioenergetic …
mitochondrial function; however, the extent to which these measures reflect the bioenergetic …
Assessing mitochondrial bioenergetics in isolated mitochondria from various mouse tissues using seahorse XF96 analyzer
A Iuso, B Repp, C Biagosch, C Terrile… - Mitochondria: Practical …, 2017 - Springer
Working with isolated mitochondria is the gold standard approach to investigate the function
of the electron transport chain in tissues, free from the influence of other cellular factors. In …
of the electron transport chain in tissues, free from the influence of other cellular factors. In …
Blood‐based bioenergetic profiling reflects differences in brain bioenergetics and metabolism
DJ Tyrrell, MS Bharadwaj, MJ Jorgensen… - Oxidative Medicine …, 2017 - Wiley Online Library
Blood‐based bioenergetic profiling provides a minimally invasive assessment of
mitochondrial health shown to be related to key features of aging. Previous studies show …
mitochondrial health shown to be related to key features of aging. Previous studies show …
[HTML][HTML] Mitochondria-targeted probes for imaging protein sulfenylation
RJ Holmila, SA Vance, X Chen, H Wu, K Shukla… - Scientific Reports, 2018 - nature.com
Mitochondrial reactive oxygen species (ROS) are essential regulators of cellular signaling,
metabolism and epigenetics underlying the pathophysiology of numerous diseases. Despite …
metabolism and epigenetics underlying the pathophysiology of numerous diseases. Despite …