Drug-induced liver injury (DILI) is an adverse reaction to drugs or other xenobiotics that
occurs either as a predictable event when an individual is exposed to toxic doses of some …

Hepatic injury and subsequent hepatic failure due to both intentional and non-intentional
overdose of acetaminophen (APAP) has affected patients for decades, and involves the …

Idiosyncratic (unpredictable) drug-induced liver injury is one of the most challenging liver
disorders faced by hepatologists, because of the myriad of drugs used in clinical practice …

Idiosyncratic drug-induced liver injury (IDILI) is a rare but potentially severe adverse drug
reaction that should be considered in patients who develop laboratory criteria for liver injury …

Objective To investigate the efficacy and safety of paracetamol (acetaminophen) in the
management of spinal pain and osteoarthritis of the hip or knee. Design Systematic review …

Paracetamol is used worldwide for its analgesic and antipyretic actions. It has a spectrum of
action similar to that of NSAIDs and resembles particularly the COX-2 selective inhibitors …

Acute liver failure is a rare disorder with high mortality and resource cost. In the developing
world, viral causes predominate, with hepatitis E infection recognised as a common cause in …

Background Drug-induced liver injury (DILI) is a common adverse event, which
compromises the safety of numerous drugs, poses a significant risk to patient health, and …

Recommendation 1: Clinicians should conduct a focused history and physical examination
to help place patients with low back pain into 1 of 3 broad categories: nonspecific low back …

Pain is a complex phenomenon caused by noxious sensory stimuli or neuropathological
mechanisms. An individual's memories, expectations, and emotions modify the experience …