The bioinorganic chemistry of mammalian metallothioneins
The functions, purposes, and roles of metallothioneins have been the subject of
speculations since the discovery of the protein over 60 years ago. This article guides …
speculations since the discovery of the protein over 60 years ago. This article guides …
Mammalian zinc transport, trafficking, and signals
RJ Cousins, JP Liuzzi, LA Lichten - Journal of Biological Chemistry, 2006 - ASBMB
Structural, catalytic, and regulatory functions of zinc in biology continue to be defined. The
number of genes coding for proteins with zinc-binding domains is conservatively estimated …
number of genes coding for proteins with zinc-binding domains is conservatively estimated …
Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response
JP Liuzzi, LA Lichten, S Rivera… - Proceedings of the …, 2005 - National Acad Sciences
Infection and inflammation produce systemic responses that include hypozincemia and
hypoferremia. The latter involves regulation of the iron transporter ferroportin 1 by hepcidin …
hypoferremia. The latter involves regulation of the iron transporter ferroportin 1 by hepcidin …
Synaptically released zinc: physiological functions and pathological effects
CJ Frederickson, AI Bush - Biometals, 2001 - Springer
In addition to its familiar role as a component of metalloproteins, zinc is also sequestered in
the presynaptic vesicles of a specialized type of neurons calledzinc-containing'neurons …
the presynaptic vesicles of a specialized type of neurons calledzinc-containing'neurons …
Advances in the structure and chemistry of metallothioneins
N Romero-Isart, M Vašák - Journal of inorganic biochemistry, 2002 - Elsevier
A low molecular weight (6–7 kDa) class of metalloproteins, designated as metallothioneins
(MTs), exhibit repeated sequence motifs of either CxC or CxxC through which mono or …
(MTs), exhibit repeated sequence motifs of either CxC or CxxC through which mono or …
Cellular mechanisms of zinc dysregulation: a perspective on zinc homeostasis as an etiological factor in the development and progression of breast cancer
S Alam, SL Kelleher - Nutrients, 2012 - mdpi.com
Worldwide, breast cancer is the most commonly diagnosed cancer among women and is the
leading cause of female cancer deaths. Zinc (Zn) functions as an antioxidant and plays a …
leading cause of female cancer deaths. Zinc (Zn) functions as an antioxidant and plays a …
The “magic numbers” of metallothionein
DEK Sutherland, MJ Stillman - Metallomics, 2011 - academic.oup.com
Metallothioneins (MT) are a family of small cysteine rich proteins, which since their discovery
in 1957, have been implicated in a range of roles including toxic metal detoxification …
in 1957, have been implicated in a range of roles including toxic metal detoxification …
Zinc transporter ZIP8 (SLC39A8) and zinc influence IFN-γ expression in activated human T cells
TB Aydemir, JP Liuzzi, S McClellan… - Journal of leukocyte …, 2009 - academic.oup.com
Dietary zinc supplement increases production of the tumor/infection-fighting cytokine IFN-γ
in T cells by increasing zinc transport from the lysosomes to the cell cytoplasm. The zinc …
in T cells by increasing zinc transport from the lysosomes to the cell cytoplasm. The zinc …
Metallothionein redox cycle and function
YJ Kang - Experimental biology and Medicine, 2006 - journals.sagepub.com
The biologic function of metallothionein (MT) has been a perplexing topic ever since the
discovery of this protein. Many studies have suggested that MT plays a role in the …
discovery of this protein. Many studies have suggested that MT plays a role in the …
Zinc transporter ZIP14 functions in hepatic zinc, iron and glucose homeostasis during the innate immune response (endotoxemia)
T Beker Aydemir, SM Chang, GJ Guthrie, AB Maki… - PloS one, 2012 - journals.plos.org
ZIP14 (slc39A14) is a zinc transporter induced in response to pro-inflammatory stimuli.
ZIP14 induction accompanies the reduction in serum zinc (hypozincemia) of acute …
ZIP14 induction accompanies the reduction in serum zinc (hypozincemia) of acute …