The bioinorganic chemistry of mammalian metallothioneins

A Krezel, W Maret - Chemical reviews, 2021 - ACS Publications
The functions, purposes, and roles of metallothioneins have been the subject of
speculations since the discovery of the protein over 60 years ago. This article guides …

Mammalian zinc transport, trafficking, and signals

RJ Cousins, JP Liuzzi, LA Lichten - Journal of Biological Chemistry, 2006 - ASBMB
Structural, catalytic, and regulatory functions of zinc in biology continue to be defined. The
number of genes coding for proteins with zinc-binding domains is conservatively estimated …

Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response

JP Liuzzi, LA Lichten, S Rivera… - Proceedings of the …, 2005 - National Acad Sciences
Infection and inflammation produce systemic responses that include hypozincemia and
hypoferremia. The latter involves regulation of the iron transporter ferroportin 1 by hepcidin …

Synaptically released zinc: physiological functions and pathological effects

CJ Frederickson, AI Bush - Biometals, 2001 - Springer
In addition to its familiar role as a component of metalloproteins, zinc is also sequestered in
the presynaptic vesicles of a specialized type of neurons calledzinc-containing'neurons …

Advances in the structure and chemistry of metallothioneins

N Romero-Isart, M Vašák - Journal of inorganic biochemistry, 2002 - Elsevier
A low molecular weight (6–7 kDa) class of metalloproteins, designated as metallothioneins
(MTs), exhibit repeated sequence motifs of either CxC or CxxC through which mono or …

Cellular mechanisms of zinc dysregulation: a perspective on zinc homeostasis as an etiological factor in the development and progression of breast cancer

S Alam, SL Kelleher - Nutrients, 2012 - mdpi.com
Worldwide, breast cancer is the most commonly diagnosed cancer among women and is the
leading cause of female cancer deaths. Zinc (Zn) functions as an antioxidant and plays a …

The “magic numbers” of metallothionein

DEK Sutherland, MJ Stillman - Metallomics, 2011 - academic.oup.com
Metallothioneins (MT) are a family of small cysteine rich proteins, which since their discovery
in 1957, have been implicated in a range of roles including toxic metal detoxification …

Zinc transporter ZIP8 (SLC39A8) and zinc influence IFN-γ expression in activated human T cells

TB Aydemir, JP Liuzzi, S McClellan… - Journal of leukocyte …, 2009 - academic.oup.com
Dietary zinc supplement increases production of the tumor/infection-fighting cytokine IFN-γ
in T cells by increasing zinc transport from the lysosomes to the cell cytoplasm. The zinc …

Metallothionein redox cycle and function

YJ Kang - Experimental biology and Medicine, 2006 - journals.sagepub.com
The biologic function of metallothionein (MT) has been a perplexing topic ever since the
discovery of this protein. Many studies have suggested that MT plays a role in the …

Zinc transporter ZIP14 functions in hepatic zinc, iron and glucose homeostasis during the innate immune response (endotoxemia)

T Beker Aydemir, SM Chang, GJ Guthrie, AB Maki… - PloS one, 2012 - journals.plos.org
ZIP14 (slc39A14) is a zinc transporter induced in response to pro-inflammatory stimuli.
ZIP14 induction accompanies the reduction in serum zinc (hypozincemia) of acute …