Unsupervised machine learning for exploratory data analysis in imaging mass spectrometry

N Verbeeck, RM Caprioli… - Mass spectrometry …, 2020 - Wiley Online Library
Imaging mass spectrometry (IMS) is a rapidly advancing molecular imaging modality that
can map the spatial distribution of molecules with high chemical specificity. IMS does not …

Mass spectrometric imaging for biomedical tissue analysis

K Chughtai, RMA Heeren - Chemical reviews, 2010 - ACS Publications
A mass spectrometer is described as the smallest weighing scale ever used in the world. 1
Mass spectrometry (MS) is a unique technique that has an interdisciplinary nature, which …

A tutorial on support vector machine-based methods for classification problems in chemometrics

J Luts, F Ojeda, R Van de Plas, B De Moor… - Analytica chimica …, 2010 - Elsevier
This tutorial provides a concise overview of support vector machines and different closely
related techniques for pattern classification. The tutorial starts with the formulation of support …

Normalization in MALDI-TOF imaging datasets of proteins: practical considerations

SO Deininger, DS Cornett, R Paape, M Becker… - Analytical and …, 2011 - Springer
Normalization is critically important for the proper interpretation of matrix-assisted laser
desorption/ionization (MALDI) imaging datasets. The effects of the commonly used …

MALDI imaging mass spectrometry for direct tissue analysis: a new frontier for molecular histology

A Walch, S Rauser, SO Deininger, H Höfler - Histochemistry and cell …, 2008 - Springer
Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is a
powerful tool for investigating the distribution of proteins and small molecules within …

Peptide and protein imaging mass spectrometry in cancer research

LA McDonnell, GL Corthals, SM Willems… - Journal of …, 2010 - Elsevier
MALDI mass spectrometry is able to acquire protein profiles directly from tissue that can
describe the levels of hundreds of distinct proteins. MALDI imaging MS can simultaneously …

MALDI imaging mass spectrometry: state of the art technology in clinical proteomics

J Franck, K Arafah, M Elayed, D Bonnel… - Molecular & Cellular …, 2009 - ASBMB
A decade after its inception, MALDI imaging mass spectrometry has become a unique
technique in the proteomics arsenal for biomarker hunting in a variety of diseases. At this …

Spatial segmentation of mass spectrometry imaging data by combining multivariate clustering and univariate thresholding

H Hu, R Yin, HM Brown, J Laskin - Analytical chemistry, 2021 - ACS Publications
Spatial segmentation partitions mass spectrometry imaging (MSI) data into distinct regions,
providing a concise visualization of the vast amount of data and identifying regions of …

Imaging mass spectrometry of thin tissue sections: a decade of collective efforts

P Chaurand - Journal of proteomics, 2012 - Elsevier
Imaging mass spectrometry (MS) allows to monitor the spatial distribution and abundance of
endogenous and administered compounds present within tissue specimens. Several …

Concise representation of mass spectrometry images by probabilistic latent semantic analysis

M Hanselmann, M Kirchner, BY Renard… - Analytical …, 2008 - ACS Publications
Imaging mass spectrometry (IMS) is a promising technology which allows for detailed
analysis of spatial distributions of (bio) molecules in organic samples. In many current …