Understanding early-life adaptive immunity to guide interventions for pediatric health

EC Semmes, JL Chen, R Goswami, TD Burt… - Frontiers in …, 2021 - frontiersin.org
Infants are capable of mounting adaptive immune responses, but their ability to develop long-
lasting immunity is limited. Understanding the particularities of the neonatal adaptive …

Phage display antibody libraries: A robust approach for generation of recombinant human monoclonal antibodies

R Kumar, HA Parray, T Shrivastava, S Sinha… - International journal of …, 2019 - Elsevier
Monoclonal antibodies (mAbs) and their derivatives have achieved remarkable success as
medicine, targeting both diagnostic and therapeutic applications associated with …

Structural insights for neutralization of Omicron variants BA. 1, BA. 2, BA. 4, and BA. 5 by a broadly neutralizing SARS-CoV-2 antibody

S Kumar, A Patel, L Lai, C Chakravarthy… - Science …, 2022 - science.org
In this study, by characterizing several human monoclonal antibodies (mAbs) isolated from
single B cells of the COVID-19–recovered individuals in India who experienced ancestral …

To bnAb or not to bnAb: defining broadly neutralising antibodies against HIV-1

SA Griffith, LE McCoy - Frontiers in immunology, 2021 - frontiersin.org
Since their discovery, antibodies capable of broad neutralisation have been at the forefront
of HIV-1 research and are of particular interest due to in vivo passive transfer studies …

[HTML][HTML] Epitope convergence of broadly HIV-1 neutralizing IgA and IgG antibody lineages in a viremic controller

V Lorin, I Fernández, G Masse-Ranson… - Journal of Experimental …, 2022 - rupress.org
Decrypting the B cell ontogeny of HIV-1 broadly neutralizing antibodies (bNAbs) is
paramount for vaccine design. Here, we characterized IgA and IgG bNAbs of three distinct B …

An overview of human anti-HIV-1 neutralizing antibodies against diverse epitopes of HIV-1

S Kumar, S Singh, K Luthra - ACS omega, 2023 - ACS Publications
In this Review, we have addressed some recent developments in the discovery and
applications of anti-human immunodeficiency virus type− 1 (HIV− 1) broadly neutralizing …

Microsecond dynamics control the HIV-1 envelope conformation

AL Bennett, R Edwards, I Kosheleva, C Saunders… - Science …, 2024 - science.org
The HIV-1 Envelope (Env) glycoprotein facilitates host cell fusion through a complex series
of receptor-induced structural changes. Although remarkable progress has been made in …

[HTML][HTML] Cross-neutralization of SARS-CoV-2 by HIV-1 specific broadly neutralizing antibodies and polyclonal plasma

N Mishra, S Kumar, S Singh, T Bansal, N Jain… - PLoS …, 2021 - journals.plos.org
Cross-reactive epitopes (CREs) are similar epitopes on viruses that are recognized or
neutralized by same antibodies. The S protein of SARS-CoV-2, similar to type I fusion …

Broadly neutralizing plasma antibodies effective against autologous circulating viruses in infants with multivariant HIV-1 infection

N Mishra, S Sharma, A Dobhal, S Kumar… - Nature …, 2020 - nature.com
Broadly neutralizing antibodies (bnAbs) develop in a subset of HIV-1 infected individuals
over 2–3 years of infection. Infected infants develop plasma bnAbs frequently and as early …

Challenges and opportunities of therapies targeting early life immunity for pediatric HIV cure

SJ Berendam, AN Nelson, B Yagnik… - Frontiers in …, 2022 - frontiersin.org
Early initiation of antiretroviral therapy (ART) significantly improves clinical outcomes and
reduces mortality of infants/children living with HIV. However, the ability of infected cells to …