Working memory is characterized by neural activity that persists during the retention interval
of delay tasks. Despite the ubiquity of this delay activity across tasks, species and …

Neuron modeling may be said to have originated with the Hodgkin and Huxley action
potential model in 1952 and Rall's models of integrative activity of dendrites in 1964. Over …

Biophysical modeling of neuronal networks helps to integrate and interpret rapidly growing
and disparate experimental datasets at multiple scales. The NetPyNE tool (www. netpyne …

Abstract Alzheimer's disease (AD), a progressive neurodegenerative disorder, is a leading
global health concern for individuals and society. However, the potential mechanisms …

Genetic studies in late-onset Alzheimer disease (LOAD) are aimed at identifying core
disease mechanisms and providing potential biomarkers and drug candidates to improve …

Objective: Like all scientific research, computational neuroscience research must be
reproducible. Big data science, including simulation research, cannot depend exclusively on …

Dendrites of cortical pyramidal cells are densely populated by hyperpolarization-activated
cyclic nucleotide-gated (HCN) channels, aka I h channels. I h channels are targeted by …

Computational neuroscience is a field that traces its origins to the efforts of Hodgkin and
Huxley, who pioneered quantitative analysis of electrical activity in the nervous system …

Signalling pathways leading to post-synaptic plasticity have been examined in many types
of experimental studies, but a unified picture on how multiple biochemical pathways …

Neurons in the central nervous system (CNS) are distinguished by the neurotransmitter
types they release, their synaptic connections, morphology, and genetic profiles. To fully …