Keratoconus (KC) is a corneal thinning disorder that leads to loss of visual acuity through
ectasia, opacity, and irregular astigmatism. It is one of the leading indicators for corneal …

The Hippo pathway is an evolutionarily conserved pathway that serves to promote cell death
and differentiation while inhibiting cellular proliferation across species. The downstream …

Abstract Purpose Desmoglein-2 (Dsg2) is a cell adhesion protein of the cadherin
superfamily. Altered Dsg2 expression is associated with tumorigenesis. This study …

While classic cadherin-actin connections in adherens junctions (AJs) have ancient origins,
intermediate filament (IF) linkages with desmosomal cadherins arose in vertebrate …

Desmoglein 3 (Dsg3) plays a crucial role in cell-cell adhesion and tissue integrity.
Increasing evidence suggests that Dsg3 acts as a regulator of cellular mechanotransduction …

Alterations of the Hippo–YAP pathway are potential targets for oral squamous cell
carcinoma (OSCC) therapy, but heterogeneity in this pathway could be responsible for …

Background: Frequent disease relapse and a lack of effective therapies result in a very poor
outcome in pancreatic ductal adenocarcinoma (PDAC) patients. Thus, identification of …

Abstract Desmoglein-3 (Dsg3), the Pemphigus Vulgaris (PV) antigen (PVA), plays an
essential role in keratinocyte cell–cell adhesion and regulates various signaling pathways …

The immunobullous condition Pemphigus Vulgaris (PV) is caused by autoantibodies
targeting the adhesion proteins of desmosomes, leading to blistering in the skin and …

The role of desmoglein-3 (DSG3) in oncogenesis is unclear. This study aimed to uncover
molecular mechanisms through comparative transcriptome analysis in oral cancer cells …