Following the impetus of early clinical and experimental investigations, in vivo and in vitro
MRS studies of tumours pointed in the eighties to the possible significance of signals arising …

N-Acetyl aspartate (NAA) is the second most abundant amino acid in the human brain. NAA
is synthesized by l-aspartate N-acetyl transferase or by cleavage from N-acetyl aspartyl …

Background: There is controversy over whether seizures, the most common manifestation of
neonatal brain injury, may themselves damage the developing brain. Objective: To …

1. Abstract Background Current concepts of Attention-Deficit/Hyperactivity Disorder (ADHD)
emphasize the role of higher-order cognitive functions and reinforcement processes …

Biochemical maturation of the brain can be studied noninvasively by 1H magnetic
resonance spectroscopy (MRS) in human infants. Detailed time courses of cerebral tissue …

Volumetric proton magnetic resonance spectroscopic imaging (MRSI) was used to generate
brain metabolite maps in 15 young and 19 elderly adult volunteers. All subjects also had …

The aims of this study were 1) to define normal perinatal maturational changes in proton
metabolite peak-area ratios in two regions of the neonatal brain, the thalamic and …

* Tel.:+ 41 31 632 8174; fax:+ 41 31 382 2486; e-mail: kreis@ insel. ch'Abbreviations-ACn:
acetylcamitine; acqs.: acquisitions; Ch: choline; CR: Cramer-Rao; Cr: total creatine (Cr+ …

Recent advances in MR-based brain imaging methods have provided unprecedented
capabilities to visualize the brain. Application of these methods has allowed identification of …

Objective: This paper examines the current literature pertaining to brain ageing. The
objective of this review is to provide an overview of the effects of ageing on brain structure …