The goal of this review is to discuss how behavioral tests in mice relate to the pathological
and neuropsychological features seen in human Alzheimer's disease (AD), and present a …

An important pathological feature of Alzheimer's disease (AD) is the presence of
extracellular senile plaques in the brain. Senile plaques are composed of aggregations of …

Inflammation is a pathological hallmark of Alzheimer's disease, and innate immune cells
have been shown to contribute to disease pathogenesis. In two transgenic models of …

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
cognitive deficits and psychiatric symptoms. The gut microbiota-brain axis plays a pivotal …

Objectives To investigate the relation between the risk of Alzheimer's disease and exposure
to benzodiazepines started at least five years before, considering both the dose-response …

Transgenic mouse models have been used extensively to model the cognitive impairments
arising from Alzheimer's disease (AD)-related pathology. However, less is known about the …

Alzheimer's disease (AD) involves progressive accumulation of amyloid β-peptide (Aβ) and
neurofibrillary pathologies, and glucose hypometabolism in brain regions critical for …

Anxiety disorders are the most prevalent group of psychiatric diseases, and have high
personal and societal costs. The search for novel pharmacological treatments for these …

The aberrant accumulation of aggregated β-amyloid peptides (Aβ) as plaques is a hallmark
of Alzheimer's disease (AD) neuropathology and reduction of Aβ has become a leading …

Anxiety disorders are common, serious and a growing health problem worldwide. However,
the causative factors, aetiology and underlying mechanisms of anxiety disorders, as for most …