Gene drives are selfish genetic elements that are transmitted to progeny at super-Mendelian
(> 50%) frequencies. Recently developed CRISPR–Cas9-based gene-drive systems are …

Mosquito-borne diseases, such as dengue and malaria, pose significant global health
burdens. Unfortunately, current control methods based on insecticides and environmental …

CRISPR-based gene-drives targeting the gene doublesex in the malaria vector Anopheles
gambiae effectively suppressed the reproductive capability of mosquito populations reared …

Invasive rodents are a major cause of environmental damage and biodiversity loss,
particularly on islands. Unlike insects, genetic biocontrol strategies including population …

The mosquito Aedes aegypti is the principal vector for arboviruses including dengue/yellow
fever, chikungunya, and Zika virus, infecting hundreds of millions of people annually …

Genetic biocontrol aims to suppress or modify populations of species to protect public
health, agriculture, and biodiversity. Advancements in genome engineering technologies …

Malaria is among the world's deadliest diseases, predominantly affecting Sub-Saharan
Africa and killing over half a million people annually. Controlling the principal vector, the …

Controlling the principal African malaria vector, the mosquito Anopheles gambiae, is
considered essential to curtail malaria transmission. However, existing vector control …

Gene drives hold promise for use in controlling insect vectors of diseases, agricultural pests,
and for conservation of ecosystems against invasive species. At the same time, this …

The ability to engineer gene drives (genetic elements that bias their own inheritance) has
sparked enthusiasm and concerns. Engineered gene drives could potentially be used to …