The machinery of exosomes: biogenesis, release, and uptake

SV Krylova, D Feng - International Journal of Molecular Sciences, 2023 - mdpi.com
Exosomes are a subtype of membrane-contained vesicles 40–200 nm in diameter that are
secreted by cells into their surroundings. By transporting proteins, lipids, mRNA, miRNA …

Exploiting the biogenesis of extracellular vesicles for bioengineering and therapeutic cargo loading

J Rädler, D Gupta, A Zickler, SEL Andaloussi - Molecular Therapy, 2023 - cell.com
Extracellular vesicles (EVs) are gaining increasing attention for diagnostic and therapeutic
applications in various diseases. These natural nanoparticles benefit from favorable safety …

Mammalian retrovirus-like protein PEG10 packages its own mRNA and can be pseudotyped for mRNA delivery

M Segel, B Lash, J Song, A Ladha, CC Liu, X Jin… - Science, 2021 - science.org
Eukaryotic genomes contain domesticated genes from integrating viruses and mobile
genetic elements. Among these are homologs of the capsid protein (known as Gag) of long …

RNA delivery by extracellular vesicles in mammalian cells and its applications

K O'Brien, K Breyne, S Ughetto, LC Laurent… - … reviews Molecular cell …, 2020 - nature.com
The term 'extracellular vesicles' refers to a heterogeneous population of vesicular bodies of
cellular origin that derive either from the endosomal compartment (exosomes) or as a result …

[HTML][HTML] Extracellular vesicles as drug delivery systems: Why and how?

OM Elsharkasy, JZ Nordin, DW Hagey… - Advanced drug delivery …, 2020 - Elsevier
Over the past decades, a multitude of synthetic drug delivery systems has been developed
and introduced to the market. However, applications of such systems are limited due to …

[HTML][HTML] Exosome engineering: Current progress in cargo loading and targeted delivery

S Fu, Y Wang, X Xia, JC Zheng - NanoImpact, 2020 - Elsevier
Exosomes, a class of small bilayer vesicles derived from virtually all eukaryotic cells, have
been exploited as a promising natural delivery platform due to their low toxicity, excellent …

Extracellular vesicles: A bright star of nanomedicine

P Wu, B Zhang, DKW Ocansey, W Xu, H Qian - Biomaterials, 2021 - Elsevier
Extracellular vesicles (EVs) have unique structural, compositional, and morphological
characteristics as well as predominant physiochemical stability and biocompatibility …

[HTML][HTML] Exosome nanovesicles: a potential carrier for therapeutic delivery

VP Chavda, A Pandya, L Kumar, N Raval, LK Vora… - Nano Today, 2023 - Elsevier
Exosomes are small nanosized biovesicles that form when multivesicular bodies and the
plasma membrane fuse and are released into the surrounding body fluids. They are best …

[HTML][HTML] Extracellular vesicles: The next generation in gene therapy delivery

R Cecchin, Z Troyer, K Witwer, KV Morris - Molecular Therapy, 2023 - cell.com
Extracellular vesicles (EVs) are esteemed as a promising delivery vehicle for various genetic
therapeutics. They are relatively inert, non-immunogenic, biodegradable, and …

Uptake, functionality, and re-release of extracellular vesicle-encapsulated cargo

K O'Brien, S Ughetto, S Mahjoum, AV Nair… - Cell reports, 2022 - cell.com
Extracellular vesicles (EVs) are membrane-encapsulated particles that carry genetically
active and protein/lipid cargo that can affect the function of the recipient cell. A number of …