A large body of evidence indicates the existence of a complex pathophysiological
relationship between cardiovascular diseases and cancer. Mitochondria are crucial …

Multiple forms of regulated cell death (RCD) have been characterized, each of which
originates from the activation of a dedicated molecular machinery. RCD can occur in purely …

Lysosomes and the endoplasmic reticulum (ER) are Ca 2+ stores mobilized by the second
messengers NAADP and IP 3, respectively. Here, we establish Ca 2+ signals between the …

Store-operated Ca2+ entry (SOCE) is activated in response to the inositol-1, 4, 5-
trisphosphate (InsP3)-dependent depletion of the endoplasmic reticulum (ER) Ca2+ store …

N-methyl-D-aspartate receptors (NMDARs) are ligand-gated ion channels that are activated
by the neurotransmitter glutamate, mediate the slow component of excitatory …

Nitric oxide (NO) represents a crucial mediator to regulate cerebral blood flow (CBF) in the
human brain both under basal conditions and in response to somatosensory stimulation. An …

Cytosolic Ca2+ signals are organized in complex spatial and temporal patterns that underlie
their unique ability to regulate multiple cellular functions. Changes in intracellular Ca2+ …

Numerous studies recently showed that the inhibitory neurotransmitter, γ-aminobutyric acid
(GABA), can stimulate cerebral angiogenesis and promote neurovascular coupling by …

A monolayer of endothelial cells lines the innermost surface of all blood vessels, thereby
coming into close contact with every region of the body and perceiving signals deriving from …

Acidic organelles act as intracellular Ca 2+ stores; they actively sequester Ca 2+ in their
lumina and release it to the cytosol upon activation of endo-lysosomal Ca 2+ channels …