The Genus Diospyros: A Review of Novel Insights into the Biological Activity and Species of Mozambican Flora

A Ribeiro, R Serrano, IBM da Silva, ET Gomes, JF Pinto… - Plants, 2023 - mdpi.com
Species of the Diospyros L. genus (Ebenaceae family) have been largely used in traditional
medicine for the treatment of several diseases, especially infectious ones. To date, active …

[HTML][HTML] Models for cytotoxicity screening of antileishmanial drugs: what has been done so far?

MBC Brioschi, EM Coser, AC Coelho… - International Journal of …, 2022 - Elsevier
A growing number of studies have demonstrated the in vitro potential of an impressive
number of antileishmanial candidates in the past years. However, the lack of uniformity …

Synthesis, in vitro Antileishmanial Efficacy and Hit/Lead Identification of Nitrofurantoin‐Triazole Hybrids

NH Zuma, J Aucamp, M Viljoen, DD N'Da - ChemMedChem, 2022 - Wiley Online Library
Leishmaniasis is a vector‐borne neglected parasitic infection affecting thousands of
individuals, mostly among populations in low‐to moderate‐income developing countries. In …

Design, synthesis, electrochemistry and anti-trypanosomatid hit/lead identification of nitrofuranylazines

M Saayman, C Kannigadu, J Aucamp… - RSC Medicinal …, 2023 - pubs.rsc.org
Chagas disease and leishmaniasis are vector-borne infectious diseases affecting both
humans and animals. These neglected tropical diseases can be fatal if not treated …

Flavonoids from Pistacia chinensis subsp. integerrima with leishmanicidal activity: computational and experimental evidence

A Rauf, U Rashid, AM Shbeer… - Natural Product …, 2024 - Taylor & Francis
Pistacia chinensis subsp. integerrima is a valuable medicinal plant as its parts and extracts
found application for treating diarrhea, fever, liver disorders, asthma, and inflammation. In …

Challenges and Tools for In Vitro Leishmania Exploratory Screening in the Drug Development Process: An Updated Review

A Cohen, N Azas - Pathogens, 2021 - mdpi.com
Leishmaniases are a group of vector-borne diseases caused by infection with the protozoan
parasites Leishmania spp. Some of them, such as Mediterranean visceral leishmaniasis, are …

[HTML][HTML] Probing O-substituted nifuroxazide analogues against Leishmania: Synthesis, in vitro efficacy, and hit/lead identification

GD Badenhorst, C Kannigadu, J Aucamp… - European Journal of …, 2022 - Elsevier
Leishmaniasis is a neglected tropical disease affecting millions of people worldwide, with
650 000 to 1.1 million new infections reported annually by the World Health Organization …

Design, synthesis, in vitro and in vivo trypanosomaticidal efficacy of novel 5-nitroindolylazines

DND David, J Aucamp, HDJ van Rensburg… - European Journal of …, 2024 - Elsevier
Leishmaniasis and trypanosomiasis rank among lethal vector-borne parasitic diseases that
are endemic in tropical and sub-tropical countries. There are currently no preventive …

Ethnomedicinal, Phytochemical, and Pharmacological Properties of Diospyros mollis Griff.: A Review

TV Chen, NT Nghia, LV Nhat Truong… - Natural Product …, 2024 - journals.sagepub.com
Objective/Background The genus Diospyros L.(Ebenaceae) includes about 778 species
worldwide, with over 500 of them known for their significant health benefits. Among them …

In Vitro and In Vivo Cysticidal Effects of Carica Papaya Cell Suspensions

C Guzmán, N Villalobos, A Ortiz Caltempa… - Infection and …, 2023 - Am Soc Microbiol
Parasitic diseases are a major public health problem worldwide. Plant-derived products
appear to be ideal candidates from a biotechnological perspective, being sustainable and …