Abstract Angiotensin (Ang)‐converting enzyme (ACE) 2 cleaves Ang‐II into the vasodilator
peptide Ang‐(1–7), thus acting as a pivotal element in balancing the local effects of these …

Effective antihypertensive therapy has made a major contribution to the reductions in the
morbidity and mortality of cardiovascular disease that have been achieved since the 1960s …

Losartan is the first orally available angiotensin-receptor antagonist without agonist
properties. Following oral administration, losartan is rapidly absorbed, reaching maximum …

The renin-angiotensin system (RAS) is recognized as a key element in blood pressure
regulation and electrolyte/fluid homeostasis. 1 As outlined in Figure 1, the RAS constitutes a …

Angiotensin II antagonists (AIIA) are part of a new rational treatment of hypertension.
Because adverse circulatory effects during anesthesia can occur in patients chronically …

The aim of this study was to compare the effect of antihypertensive treatment with valsartan
or cavedilol on sexual activity in hypertensive men who were never treated for hypertension …

Background Chronic activation of the renin-angiotensin system (RAS) plays an important
role in the pathogenesis of heart failure. Increasing evidence indicates that other than the …

A-II exerts its activity on various target tissues by binding to its receptors. The discovery of
local RASs and A-II receptors within various tissues has generated interest in the clinical …

Extensive research has been conducted to elucidate and substantiate the crucial role of the
Renin-Angiotensin System (RAS) in the pathogenesis of hypertension, cardiovascular …

OBJECTIVES To examine whether blocking of the renin-angiotensin system (RAS) at the
angiotensin II type 1 (AT1) receptor site is accompanied by changes in the oxidative stress …