Osteoarthritis comprises several joint disorders characterized by articular cartilage
degeneration and persistent pain, causing disability and economic burden. The incidence of …

OA is a painful joint disease that predominantly affects the elderly. Pain is the primary
symptom of OA, and it can present as either intermittent or constant. OA pain mechanisms …

Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide
association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and …

Background This study aimed to investigate the effect of bone marrow mesenchymal stem
cell (BMSC)-derived exosome injection on cartilage damage and pain relief in both in vitro …

Objective This study aims to explore the relationship between PI3K/AKT/mTOR signaling
pathway and autophagy of articular chondrocytes in rats with osteoarthritis (OA). Methods …

Pain due to osteoarthritis (OA) is one of the most frequent causes of chronic pain. However,
the mechanisms of OA pain are poorly understood. This review addresses the mechanisms …

Chronic pain is a global problem that has reached epidemic proportions. An estimated 20%
of adults suffer from pain, and another 10% are diagnosed with chronic pain each year …

Osteoarthritis (OA) is the most common form of joint disease and a major cause of pain and
disability in the adult population. Interestingly, there are patients with symptomatic OA …

Purpose The aim of this study was to evaluate the therapeutic efficacy and safety of
mesenchymal stem cells (MSCs) for the treatment of patients with knee osteoarthritis (OA) …

Osteoarthritis (OA) is a leading cause of pain and disability worldwide. Despite the existence
of evidence-based treatments and guidelines, substantial gaps remain in the quality of OA …