Fluid transport in the brain

MK Rasmussen, H Mestre… - Physiological …, 2022 - journals.physiology.org
The brain harbors a unique ability to, figuratively speaking, shift its gears. During
wakefulness, the brain is geared fully toward processing information and behaving, while …

The role of brain vasculature in neurodegenerative disorders

MD Sweeney, K Kisler, A Montagne, AW Toga… - Nature …, 2018 - nature.com
Adequate supply of blood and structural and functional integrity of blood vessels are key to
normal brain functioning. On the other hand, cerebral blood flow shortfalls and blood–brain …

[HTML][HTML] A human brain vascular atlas reveals diverse mediators of Alzheimer's risk

AC Yang, RT Vest, F Kern, DP Lee, M Agam, CA Maat… - Nature, 2022 - nature.com
The human brain vasculature is of great medical importance: its dysfunction causes
disability and death, and the specialized structure it forms—the blood–brain barrier …

Functional ultrasound localization microscopy reveals brain-wide neurovascular activity on a microscopic scale

N Renaudin, C Demené, A Dizeux, N Ialy-Radio… - Nature …, 2022 - nature.com
The advent of neuroimaging has increased our understanding of brain function. While most
brain-wide functional imaging modalities exploit neurovascular coupling to map brain …

The neurovascular unit coming of age: a journey through neurovascular coupling in health and disease

C Iadecola - Neuron, 2017 - cell.com
The concept of the neurovascular unit (NVU), formalized at the 2001 Stroke Progress
Review Group meeting of the National Institute of Neurological Disorders and Stroke …

Neurovascular and cognitive dysfunction in hypertension: epidemiology, pathobiology, and treatment

C Iadecola, RF Gottesman - Circulation research, 2019 - Am Heart Assoc
Hypertension has emerged as a leading cause of age-related cognitive impairment. Long
known to be associated with dementia caused by vascular factors, hypertension has more …

Neurovascular coupling: motive unknown

PJ Drew - Trends in neurosciences, 2022 - cell.com
In the brain, increases in neural activity drive changes in local blood flow via neurovascular
coupling. The common explanation for increased blood flow (known as functional …

Cerebrospinal fluid flow

DH Kelley, JH Thomas - Annual Review of Fluid Mechanics, 2023 - annualreviews.org
Circulation of cerebrospinal fluid and interstitial fluid around the central nervous system and
through the brain transports not only those water-like fluids but also any solutes they carry …

Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer's disease mouse models

JC Cruz Hernández, O Bracko, CJ Kersbergen… - Nature …, 2019 - nature.com
Cerebral blood flow (CBF) reductions in Alzheimer's disease patients and related mouse
models have been recognized for decades, but the underlying mechanisms and resulting …

Mapping the fine-scale organization and plasticity of the brain vasculature

C Kirst, S Skriabine, A Vieites-Prado, T Topilko… - Cell, 2020 - cell.com
The cerebral vasculature is a dense network of arteries, capillaries, and veins. Quantifying
variations of the vascular organization across individuals, brain regions, or disease models …