Stress urinary incontinence animal models as a tool to study cell-based regenerative therapies targeting the urethral sphincter

B Herrera-Imbroda, MF Lara, A Izeta, KD Sievert… - Advanced drug delivery …, 2015 - Elsevier
Urinary incontinence (UI) is a major health problem causing a significant social and
economic impact affecting more than 200 million people (women and men) worldwide. Over …

Current practice in animal models for pelvic floor dysfunction

F Fang, Z Zhao, J Xiao, J Wen, J Wu, Y Miao - International Urogynecology …, 2023 - Springer
Introduction and hypothesis The objective was to explore the current practice of using
animal models for female pelvic floor dysfunction (PFD). Methods By applying PFD and …

Regenerative medicine therapies for stress urinary incontinence

JK Williams, A Dean, G Badlani, KE Andersson - The Journal of Urology, 2016 - Elsevier
Purpose We summarize the current state of knowledge regarding cell therapy for stress
urinary incontinence and introduce new approaches of using regenerative pharmacology as …

Intraurethral co-transplantation of bone marrow mesenchymal stem cells and muscle-derived cells improves the urethral closure

A Burdzinska, B Dybowski… - Stem Cell Research & …, 2018 - Springer
Background Cell therapy constitutes an attractive alternative to treat stress urinary
incontinence. Although promising results have been demonstrated in this field, the …

Animal models, treatment options, and biomaterials for female stress urinary incontinence

X Tan, G Li, C Li, C Kong, H Li, S Wu - Frontiers in Bioengineering …, 2024 - frontiersin.org
In the quest to tackle stress urinary incontinence (SUI), the synthesis of cutting-edge
biomaterials and regenerative materials has emerged as a promising frontier. Briefly, animal …

Large animal models for investigating cell therapies of stress urinary incontinence

B Amend, N Harland, J Knoll, A Stenzl… - International Journal of …, 2021 - mdpi.com
Stress urinary incontinence (SUI) is a significant health concern for patients affected,
impacting their quality of life severely. To investigate mechanisms contributing to SUI …

Precise injection of human mesenchymal stromal cells in the urethral sphincter complex of Göttingen minipigs without unspecific bulking effects

B Amend, A Kelp, M Vaegler, M Klünder… - Neurourology and …, 2017 - Wiley Online Library
Aim To investigate if injection of cells in the urethral sphincter complex causes unspecific
bulking effects. Methods Human mesenchymal stromal cells were isolated, expanded, and …

Catheterization of the urethra in female pigs

GC Musk, M Zwierzchoniewska, B He - Laboratory animals, 2015 - journals.sagepub.com
Female pigs are commonly utilized as an animal model for biomedical research and require
urethral catheterization. Sixteen pigs were anaesthetized for research purposes and …

Urinary bladder catheterisation of female pigs: Influence of bladder content and Escherichia coli urinary tract infection on procedural outcome

K Stærk, L Langhorn, B Halle… - Laboratory …, 2024 - journals.sagepub.com
Catheterisation of the urinary bladder is needed in many types of human disease models in
pigs. Based on our extensive experience with the pig as an infection model, we here …

The effect of endoscopic administration of autologous porcine muscle-derived cells into the urethral sphincter

A Burdzińska, R Crayton, B Dybowski, M Idziak, K Gala… - Urology, 2013 - Elsevier
Objective To verify the fate of autologous porcine myogenic cells after endoscopic
administration into the urethral sphincter. Methods This study was performed on pig animal …