Immunotherapy has emerged as a promising treatment paradigm for many malignancies
and is transforming the drug development landscape. Although immunotherapeutic agents …

Immunotherapy is revolutionizing cancer treatment; however, complete responses are
achieved in only a small fraction of patients and tumor types. Thus, there is an urgent need …

Abstract Coronavirus disease 2019 (COVID-19) is an infectious disease that can present as
an uncontrolled, hyperactive immune response, causing severe immunological injury …

Patient-derived xenograft (PDX) models are created by engraftment of patient tumor tissues
into immunocompetent mice. Since a PDX model retains the characteristics of the primary …

Mice repopulated with human hematopoietic cells are a powerful tool for the study of human
hematopoiesis and immune function in vivo. However, existing humanized mouse models …

Fundamental cancer research and the development of efficacious antineoplastic treatments
both rely on experimental systems in which the relationship between malignant cells and …

CD47 is a broadly expressed membrane protein that interacts with the myeloid inhibitory
immunoreceptor SIRPα (also termed CD172a or SHPS-1). SIRPα is the prototypic member …

Foreign particles and cells are cleared from the body by phagocytes that must also
recognize and avoid clearance of" self" cells. The membrane protein CD47 is reportedly a" …

Significant advances in our understanding of the in vivo functions of human cells and tissues
and the human immune system have resulted from the development of'humanized'mouse …

The cancer stem cell (CSC) concept has important therapeutic implications, but its
investigation has been hampered both by a lack of consistency in the terms used for these …