There is increasing interest in the origins of chronic obstructive pulmonary disease (COPD),
as it is envisaged that preventive efforts and treatment can modify its clinical course. The …

The pathophysiology of chronic obstructive pulmonary disease (COPD) and the undisputed
role of innate immune cells in this condition have dominated the field in the basic research …

Normal gas exchange after birth requires functional lung alveolar units that are lined with
epithelial cells, parts of which are intricately fused with microvascular capillaries. A …

COPD poses a significant global public health challenge, primarily characterised by
irreversible airflow restriction and persistent respiratory symptoms. The hallmark pathology …

Sepsis and sepsis‐associated lung inflammation significantly contribute to the morbidity and
mortality of critical illness. Here, we examined the hypothesis that neuronal guidance …

Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality. Cigarette
smoke is the cause of COPD. However, only a fraction of current and/or former smokers …

Smoking-related lung diseases are among the most preventable and incurable ailments in
the world. Smokers are at increased risk of developing chronic obstructive pulmonary …

Inflammatory organ injury and sepsis have profound impacts on the morbidity and mortality
of surgical and critical care patients. MicroRNAs are small RNAs composed of 20–25 …

Introduction: Sulfur mustard (SM) is an extremely toxic gas used in chemical warfare to
cause massive lung injury and death. Victims exposed to SM gas acutely present with …

Abstract Background Alpha-1 antitrypsin (AAT) is a major serine protease inhibitor. AAT
deficiency (AATD) is a genetic disorder characterized by early-onset severe emphysema. In …