Transmembrane potassium (K) gradients are key determinants of membrane potential that
can modulate action potentials, control muscle contractility, and influence ion channel and …

Consumption of low dietary potassium, common with ultraprocessed foods, activates the
thiazide-sensitive sodium chloride cotransporter (NCC) via the w ith no (K) lysine …

The activity of the Na+-Cl-cotransporter (NCC) in the distal convoluted tubule (DCT) is finely
tuned by phosphorylation networks involving serine/threonine kinases and phosphatases …

Dietary potassium (K+) supplementation is associated with a lowering effect in blood
pressure (BP), but not all studies agree. Here, we examined the effects of short-and long …

The primary structure of the thiazide-sensitive NaCl cotransporter (NCC) was resolved 30
years ago by the molecular identification of the cDNA encoding this cotransporter, from the …

Vasopressin regulates water homeostasis via the V2 receptor in the kidney at least in part
through protein kinase A (PKA) activation. Vasopressin, through an unknown pathway …

This review highlights the molecular basis of salt sensitivity in hypertension, with a focus on
the regulation of sodium transport in the distal nephron. Sodium reabsorption in this region …

Chronic kidney disease (CKD) is a common clinical disease with an increasing incidence,
affecting 10 to 15% of the world's population. Hypertension is the most common and …

The Na+-Cl− cotransporter (NCC; SLC12A3) is a highly regulated integral membrane
protein that is known to exist as three splice variants in primates. Its primary role in the …

The thiazide-sensitive sodium chloride cotransporter (NCC) plays a vital role in maintaining
sodium (Na+) and potassium (K+) homeostasis. NCC activity is modulated by with-no-lysine …