During oncogenesis, cancer not only escapes the body's regulatory mechanisms, but also
gains the ability to affect local and systemic homeostasis. Specifically, tumors produce …

Lipids are essential constituents for malignant tumors, as they are absolutely required for
tumor growth and dissemination. Provided by the tumor microenvironment (TME) or by …

Cholesterol is a multifaceted metabolite that is known to modulate processes in cancer,
atherosclerosis, and autoimmunity. A common denominator between these diseases …

Novel pathways of vitamin D3, lumisterol 3 (L3), and tachysterol 3 (T3) activation have been
discovered, initiated by CYP11A1 and/or CYP27A1 in the case of L3 and T3. The resulting …

Despite unprecedented responses of some cancers to immune checkpoint blockade (ICB)
therapies, the application of checkpoint inhibitors in pancreatic cancer has been …

Glucocorticoids are steroid hormones with potent immunosuppressive properties. Their
primary source is the adrenals, where they are generated via de novo synthesis from …

CYP11A1, a member of the cytochrome P450 family, plays several key roles in the human
body. It catalyzes the first and rate-limiting step in steroidogenesis, converting cholesterol to …

Historically tools and technologies facilitated scientific discoveries. Steroid hormone
research is not an exception. Unfortunately, the dramatic advancement of the field faded this …

Regulatory T (Treg) cells contribute to immune homeostasis but suppress immune
responses to cancer. Strategies to disrupt Treg cell–mediated cancer immunosuppression …

The immune system plays critical roles in both autoimmunity and cancer, diseases at
opposite ends of the immune spectrum. Autoimmunity arises from loss of T cell tolerance …