The plasma membrane in eukaryotic cells contains microdomains that are enriched in
certain glycosphingolipids, gangliosides, and sterols (such as cholesterol) to form …

Cholesterol is essential for neuronal physiology, both during development and in the adult
life: as a major component of cell membranes and precursor of steroid hormones, it …

Glycerol-based ether lipids including ether phospholipids form a specialized branch of lipids
that in mammals require peroxisomes for their biosynthesis. They are major components of …

Alzheimer's disease (AD) is a neurodegenerative disorder that is one of the most
devastating and widespread diseases worldwide, mainly affecting the aging population. One …

DHA (docosahexaenoic acid) is perhaps the most pleiotropic molecule in nerve cell biology.
This long-chain highly unsaturated fatty acid has evolved to accomplish essential functions …

The emerging diverse roles of ether (phospho) lipids in nervous system development and
function in health and disease are currently attracting growing interest. Plasmalogens, a …

Significance: Epidemiological studies indicate that metabolic disorders are associated with
an increased risk for Alzheimer's disease (AD). Metabolic remodeling occurs in the central …

The presence of lipid alterations in lipid rafts from the frontal cortex in late stages of
Alzheimer's disease (AD) has been recently demonstrated. Here, we have isolated and …

Tau hyperphosphorylation is the first step of neurofibrillary tangle (NFT) formation. In the
present study, samples of the entorhinal cortex (EC) and frontal cortex area 8 (FC) of cases …

Due to their unique chemical structure, plasmalogens do not only exhibit distinct biophysical
and biochemical features, but require specialized pathways of biosynthesis and …