Abstract The flavonoids, baicalin (5, 6-dihydroxy-2-phenyl-4H-1-benzopyran-4-one-7-Od-β-
glucuronic acid) 1 and its aglycone, baicalein 2 are found in edible medicinal plants …

The ability to adapt and respond to nutrients is an ancient cellular function, conserved from
unicellular to the most complex multicellular organisms, including mammals. Mammals …

Alcoholic fatty liver is associated with inhibition of sirtuin 1 (SIRT1) and AMP-activated
kinase (AMPK), two critical signaling molecules regulating the pathways of hepatic lipid …

The mechanism for how metformin activates AMPK (AMP-activated kinase) was investigated
in isolated skeletal muscle L6 cells. A widely held notion is that inhibition of the …

Several medicinal plants that stimulate glucose uptake in skeletal muscle cells were
identified from among species used by the Cree of Eeyou Istchee of northern Quebec to treat …

Curcumin has been reported to have the potential to prevent obesity as well as cancers. The
downstream targets regulated by AMP-activated protein kinase (AMPK) for inhibiting …

AMP-activated protein kinase (AMPK), a master regulator of cellular energy homeostasis
and a central player in glucose and lipid metabolism, is potentially implicated in the …

Genistein, the major isoflavone in soybean, was recently reported to exert beneficial effects
in metabolic disorders and inflammatory diseases. In the present study, we investigated the …

Alzheimer's disease (AD) is the general consequence of dementia and is diagnostic
neuropathology by the cumulation of amyloid-beta (Aβ) protein aggregates, which are …

In the liver, adiponectin regulates both glucose and lipid metabolism and exerts an insulin-
sensitizing effect. The binding of adiponectin with its specific receptors induces the activation …