[HTML][HTML] The double-edged roles of ROS in cancer prevention and therapy

Y Wang, H Qi, Y Liu, C Duan, X Liu, T Xia, D Chen… - Theranostics, 2021 - ncbi.nlm.nih.gov
Reactive oxygen species (ROS) serve as cell signaling molecules generated in oxidative
metabolism and are associated with a number of human diseases. The reprogramming of …

Antioxidant therapy in cancer: rationale and progress

M Luo, L Zhou, Z Huang, B Li, EC Nice, J Xu, C Huang - Antioxidants, 2022 - mdpi.com
Cancer is characterized by increased oxidative stress, an imbalance between reactive
oxygen species (ROS) and antioxidants. Enhanced ROS accumulation, as a result of …

Multifaceted role of redox pattern in the tumor immune microenvironment regarding autophagy and apoptosis

Y Ren, R Wang, S Weng, H Xu, Y Zhang, S Chen… - Molecular Cancer, 2023 - Springer
The reversible oxidation-reduction homeostasis mechanism functions as a specific signal
transduction system, eliciting related physiological responses. Disruptions to redox …

Iron load toxicity in medicine: from molecular and cellular aspects to clinical implications

GJ Kontoghiorghes - International Journal of Molecular Sciences, 2023 - mdpi.com
Iron is essential for all organisms and cells. Diseases of iron imbalance affect billions of
patients, including those with iron overload and other forms of iron toxicity. Excess iron load …

Targeting reactive oxygen species capacity of tumor cells with repurposed drug as an anticancer therapy

J Wang, D Sun, L Huang, S Wang… - Oxidative medicine and …, 2021 - Wiley Online Library
Accumulating evidence shows that elevated levels of reactive oxygen species (ROS) are
associated with cancer initiation, growth, and response to therapies. As concentrations …

Diffuse Pleural Mesothelioma: Advances in Molecular Pathogenesis, Diagnosis, and Treatment

CA Febres-Aldana, R Fanaroff, M Offin… - Annual Review of …, 2024 - annualreviews.org
Diffuse pleural mesothelioma (DPM) is a highly aggressive malignant neoplasm arising from
the mesothelial cells lining the pleural surfaces. While DPM is a well-recognized disease …

Innovative delivery and release systems for antioxidants and other active substances in the treatment of cancer

Z Sezgin-Bayindir, S Losada-Barreiro… - Pharmaceuticals, 2023 - mdpi.com
Cancer is one of the major diseases leading to death worldwide, and the fight against the
disease is still challenging. Cancer diseases are usually associated with increased oxidative …

Chronic Inflammation, Oxidative Stress and Metabolic Plasticity: Three Players Driving the Pro-Tumorigenic Microenvironment in Malignant Mesothelioma

I Fiorilla, S Martinotti, AM Todesco, G Bonsignore… - Cells, 2023 - mdpi.com
Malignant pleural mesothelioma (MPM) is a lethal and rare cancer, even if its incidence has
continuously increased all over the world. Asbestos exposure leads to the development of …

Dual inhibition of CDK4/6 and PI3K/AKT/mTOR signaling impairs energy metabolism in MPM cancer cells

M Bonelli, R Terenziani, S Zoppi, C Fumarola… - International Journal of …, 2020 - mdpi.com
Background: Malignant pleural mesothelioma (MPM) is an aggressive malignancy
associated to asbestos exposure. One of the most frequent genetic alteration in MPM …

Development of cancer metabolism as a therapeutic target: new pathways, patient studies, stratification and combination therapy

AL Harris - British Journal of Cancer, 2020 - nature.com
Cancer metabolism has undergone a resurgence in the last decade, 70 years after Warburg
described aerobic glycolysis as a feature of cancer cells. A wide range of techniques have …