Transcription factors serve critical roles in the progressive development of general body
plan, organ commitment, and finally, specific cell types. It has been the hope of most …

The fibroblast growth factor (FGF) family consists of at least 15 structurally related
polypeptide growth factors. Their expression is controlled at the levels of transcription …

▪ Abstract Many organs including the mammalian lung and vascular system consist of
branched tubular networks that transport essential gases or fluids, but the genetic programs …

An inroad into an understanding of the complex molecular interactions on which
development is based can be achieved by uncovering the minimum requirements that …

Steroid hormones are ancient signaling molecules found in vertebrates and insects alike.
Both taxa show intriguing parallels with respect to how steroids function and how their …

The establishment of branched tubular epithelial structures is critical for the viability of
multicellular organisms: the tracheal system in Drosophila and the vertebrate lung being two …

The development of Drosophila trachea is under the control of spatially and/or quantitatively
regulated activity of BREATHLESS FGF receptor, which is also essential for midline glial …

The Midline Glia of Drosophila are required for nervous system morphogenesis and midline
axon guidance during embryogenesis. In origin, gene expression and function, this lineage …

A cascade of 20-hydroxyecdysone–mediated gene expression and repression initiates larva-
to-pupa metamorphosis. We recently showed that two transcription factors, BmPOUM2 and …

Epithelial tubular organs are essential for life in higher organisms and include the pancreas
and other secretory organs that function as biological factories for the synthesis and delivery …