Advances in the clinical management of uveal melanoma

RD Carvajal, JJ Sacco, MJ Jager… - Nature Reviews …, 2023 - nature.com
Melanomas arising in the uveal tract of the eye are a rare form of the disease with a biology
and clinical phenotype distinct from their more common cutaneous counterparts. Treatment …

[HTML][HTML] Uveal melanoma: current evidence on prognosis, treatment and potential developments

MC Gelmi, MJ Jager - Asia-Pacific Journal of Ophthalmology, 2024 - Elsevier
Uveal Melanoma (UM) is a rare disease, yet it is the most common primary intraocular
malignancy in adult patients. Despite continuous advancements and research, the risk of …

Multifunctional nanoparticles precisely reprogram the tumor microenvironment and potentiate antitumor immunotherapy after near-infrared-II light-mediated …

Y Ge, J Zhang, K Jin, Z Ye, W Wang, Z Zhou, J Ye - Acta Biomaterialia, 2023 - Elsevier
Mild-temperature photothermal therapy (mild PTT) is a safe and efficient antitumor therapy.
However, mild PTT alone usually fails to activate the immune response and prevent tumor …

Potential of aqueous humor as a liquid biopsy for uveal melanoma

DH Im, CC Peng, L Xu, ME Kim, D Ostrow… - International Journal of …, 2022 - mdpi.com
Tumor biopsy can identify prognostic biomarkers for metastatic uveal melanoma (UM),
however aqueous humor (AH) liquid biopsy may serve as an adjunct. This study …

A prognostic classification system for uveal melanoma based on a combination of patient age and sex, the American Joint Committee on Cancer and the Cancer …

VT Gill, S Sabazade, C Herrspiegel… - Acta …, 2023 - Wiley Online Library
Purpose To revisit the independent importance of ciliary body involvement (CBI), monosomy
3 (M3), tumour size, histological and clinical factors in uveal melanoma (UM) and to devise a …

Investigating vitreous cytokines in choroidal melanoma

H Demirci, L Tang, FY Demirci, C Ozgonul, S Weber… - Cancers, 2023 - mdpi.com
Simple Summary Uveal melanoma (UM) is a rare cancer highly prone to metastasis.
Metastatic risk is currently predicted using clinical and/or tumor biopsy-based information …

[HTML][HTML] Improved staging of ciliary body and choroidal melanomas based on estimation of tumor volume and competing risk analyses

G Stålhammar, SE Coupland, KG Ewens, A Ganguly… - Ophthalmology, 2024 - Elsevier
Purpose The current, 8th edition of the American Joint Committee on Cancer (AJCC)
anatomic classification and staging model for uveal melanoma does not fully separate …

PRAME Expression: A Target for Cancer Immunotherapy and a Prognostic Factor in Uveal Melanoma

MC Gelmi, G Gezgin… - … & Visual Science, 2023 - iovs.arvojournals.org
Purpose: Uveal melanoma (UM) is a rare disease with a high mortality, and new therapeutic
options are being investigated. Preferentially Expressed Antigen in Melanoma (PRAME) is a …

A novel glycolysis-related signature for predicting the prognosis and immune infiltration of uveal melanoma

X Guo, X Yu, Y Zhang, H Luo, R Huang, Y Zeng… - Ophthalmic …, 2023 - karger.com
Introduction: As the most common aggressive intraocular cancer in adults, uveal melanoma
(UVM) threatens the survival and vision of many people. Glycolysis is a novel hallmark of …

Time trends in the treatment and survival of 5036 uveal melanoma patients in The Netherlands over a 30-year period

TML Tong, E Bastiaannet, FM Speetjens, CU Blank… - Cancers, 2023 - mdpi.com
Simple Summary Uveal melanoma (UM) is the most common eye tumor in adults. It is
associated with dismal survival once metastasized. The treatment landscape has changed …