Abstract β-Lapachone (β-lap, 1), an ortho-naphthoquinone natural product isolated from the
lapacho tree (Tabebuia avellanedae) in many regions of South America, has received …

Lawsone (1) is a special naphthoquinone that is useful for many applications in various
scientific and technological fields. For over 100 years, it has been used as the starting …

This review demonstrates the importance of plants as sources of molecules used in
anticancer therapies. The approach is performed by relating the active molecules to their …

The worldwide COVID-19 pandemic caused by the coronavirus SARS-CoV-2 urgently
demands novel direct antiviral treatments. The main protease (Mpro) and papain-like …

This review article summarizes recent applications of electrochemical techniques to redox-
active drug development and mechanistic studies. It includes a general introduction to the …

Using machine learning, targets were identified for β-lapachone. Resorting to biochemical
assays, β-lapachone was validated as a potent, ligand efficient, allosteric and reversible …

Abstract Selenium-containing quinone-based 1, 2, 3-triazoles were synthesized using click
chemistry, the copper catalyzed azide-alkyne 1, 3-dipolar cycloaddition, and evaluated …

Continuing our screening program for novel anti-parasite compounds, we synthesized
seven 1, 4-naphthoquinones coupled to 1, 2, 3-triazoles, five nor-β-lapachone-based 1, 2, 3 …

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Compounds featuring weakly-coordinating N-oxides or carbonyl groups, as for instance,
quinoline N-oxide and quinonoid systems represent important structural scaffolds with …