Neurotoxicity in acute and repeated organophosphate exposure

SX Naughton, AV Terry Jr - Toxicology, 2018 - Elsevier
The term organophosphate (OP) refers to a diverse group of chemicals that are found in
hundreds of products worldwide. As pesticides, their most common use, OPs are clearly …

Health consequences of exposure to aircraft contaminated air and fume events: a narrative review and medical protocol for the investigation of exposed aircrew and …

J Burdon, LT Budnik, X Baur, G Hageman… - Environmental …, 2023 - Springer
Thermally degraded engine oil and hydraulic fluid fumes contaminating aircraft cabin air
conditioning systems have been well documented since the 1950s. Whilst …

Melatonin improves brain function in a model of chronic Gulf War Illness with modulation of oxidative stress, NLRP3 inflammasomes, and BDNF-ERK-CREB pathway …

LN Madhu, M Kodali, S Attaluri, B Shuai, L Melissari… - Redox Biology, 2021 - Elsevier
Persistent cognitive and mood dysfunction is the primary CNS symptom in veterans afflicted
with Gulf War Illness (GWI). This study investigated the efficacy of melatonin (MEL) for …

In-vivo imaging of neuroinflammation in veterans with Gulf War illness

Z Alshelh, DS Albrecht, C Bergan, O Akeju… - Brain, behavior, and …, 2020 - Elsevier
Abstract Gulf War Illness (GWI) is a chronic disorder affecting approximately 30% of the
veterans who served in the 1991 Gulf War. It is characterised by a constellation of symptoms …

Neuroinflammation in Gulf War Illness is linked with HMGB1 and complement activation, which can be discerned from brain-derived extracellular vesicles in the blood

LN Madhu, S Attaluri, M Kodali, B Shuai… - Brain, behavior, and …, 2019 - Elsevier
Cognitive dysfunction and neuroinflammation are conspicuously observed in Gulf War
Illness (GWI). We investigated whether brain inflammation in GWI is associated with …

Gulf War illness: mechanisms underlying brain dysfunction and promising therapeutic strategies

B Dickey, LN Madhu, AK Shetty - Pharmacology & therapeutics, 2021 - Elsevier
Abstract Gulf War Illness (GWI), a chronic multisymptom health problem, afflicts~ 30% of
veterans served in the first GW. Impaired brain function is among the most significant …

Neuropsychological functioning in military pesticide applicators from the Gulf War: Effects on information processing speed, attention and visual memory

K Sullivan, M Krengel, W Bradford, C Stone… - Neurotoxicology and …, 2018 - Elsevier
Abstract 1991 Gulf War (GW) veterans continue to experience debilitating cognitive and
mood problems more than two decades following their return from deployment. Suspected …

Curcumin treatment leads to better cognitive and mood function in a model of Gulf War Illness with enhanced neurogenesis, and alleviation of inflammation and …

M Kodali, B Hattiangady, GA Shetty, A Bates… - Brain, behavior, and …, 2018 - Elsevier
Diminished cognitive and mood function are among the most conspicuous symptoms of Gulf
War Illness (GWI). Our previous studies in a rat model of GWI have demonstrated that …

Monosodium luminol reinstates redox homeostasis, improves cognition, mood and neurogenesis, and alleviates neuro-and systemic inflammation in a model of Gulf …

AK Shetty, S Attaluri, M Kodali, B Shuai, GA Shetty… - Redox biology, 2020 - Elsevier
Enduring brain dysfunction is amid the highly manifested symptoms in veterans with Gulf
War Illness (GWI). Animal studies have established that lasting brain dysfunction in GWI is …

Acetylcholinesterase inhibitor exposures as an initiating factor in the development of Gulf War Illness, a chronic neuroimmune disorder in deployed veterans

LT Michalovicz, KA Kelly, K Sullivan, JP O'Callaghan - Neuropharmacology, 2020 - Elsevier
Abstract Gulf War Illness (GWI) is a chronic multi-symptom disorder, characterized by
symptoms such as fatigue, pain, cognitive and memory impairment, respiratory, skin and …