Polygenic scores: prediction versus explanation
R Plomin, S Von Stumm - Molecular psychiatry, 2022 - nature.com
During the past decade, polygenic scores have become a fast-growing area of research in
the behavioural sciences. The ability to directly assess people's genetic propensities has …
the behavioural sciences. The ability to directly assess people's genetic propensities has …
Twin studies to GWAS: there and back again
The field of human behavioral genetics has come full circle. It began by using twin/family
studies to estimate the relative importance of genetic and environmental influences. As large …
studies to estimate the relative importance of genetic and environmental influences. As large …
[HTML][HTML] Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals
We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a
sample of~ 3 million individuals and identify 3,952 approximately uncorrelated genome …
sample of~ 3 million individuals and identify 3,952 approximately uncorrelated genome …
Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects
Estimates from genome-wide association studies (GWAS) of unrelated individuals capture
effects of inherited variation (direct effects), demography (population stratification …
effects of inherited variation (direct effects), demography (population stratification …
Mendelian imputation of parental genotypes improves estimates of direct genetic effects
Abstract Effects estimated by genome-wide association studies (GWASs) include effects of
alleles in an individual on that individual (direct genetic effects), indirect genetic effects (for …
alleles in an individual on that individual (direct genetic effects), indirect genetic effects (for …
Modeling assortative mating and genetic similarities between partners, siblings, and in-laws
Assortative mating on heritable traits can have implications for the genetic resemblance
between siblings and in-laws in succeeding generations. We studied polygenic scores and …
between siblings and in-laws in succeeding generations. We studied polygenic scores and …
Within-sibship GWAS improve estimates of direct genetic effects
Estimates from genome-wide association studies (GWAS) represent a combination of the
effect of inherited genetic variation (direct effects), demography (population stratification …
effect of inherited genetic variation (direct effects), demography (population stratification …
Causal inference with genetic data: Past, present, and future
JB Pingault, R Richmond… - Cold Spring …, 2022 - perspectivesinmedicine.cshlp.org
The set of methods discussed in this collection has emerged from the convergence of two
scientific fields—genetics and causal inference. In this introduction, we discuss relevant …
scientific fields—genetics and causal inference. In this introduction, we discuss relevant …
The genetically informed neurobiology of addiction (GINA) model
Addictions are heritable and unfold dynamically across the lifespan. One prominent
neurobiological theory proposes that substance-induced changes in neural circuitry promote …
neurobiological theory proposes that substance-induced changes in neural circuitry promote …
Maximizing the value of twin studies in health and behaviour
FA Hagenbeek, JS Hirzinger, S Breunig… - Nature Human …, 2023 - nature.com
In the classical twin design, researchers compare trait resemblance in cohorts of identical
and non-identical twins to understand how genetic and environmental factors correlate with …
and non-identical twins to understand how genetic and environmental factors correlate with …