Polygenic scores: prediction versus explanation

R Plomin, S Von Stumm - Molecular psychiatry, 2022 - nature.com
During the past decade, polygenic scores have become a fast-growing area of research in
the behavioural sciences. The ability to directly assess people's genetic propensities has …

Twin studies to GWAS: there and back again

NP Friedman, MT Banich, MC Keller - Trends in cognitive sciences, 2021 - cell.com
The field of human behavioral genetics has come full circle. It began by using twin/family
studies to estimate the relative importance of genetic and environmental influences. As large …

[HTML][HTML] Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals

A Okbay, Y Wu, N Wang, H Jayashankar, M Bennett… - Nature …, 2022 - nature.com
We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a
sample of~ 3 million individuals and identify 3,952 approximately uncorrelated genome …

Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects

LJ Howe, MG Nivard, TT Morris, AF Hansen… - Nature …, 2022 - nature.com
Estimates from genome-wide association studies (GWAS) of unrelated individuals capture
effects of inherited variation (direct effects), demography (population stratification …

Mendelian imputation of parental genotypes improves estimates of direct genetic effects

AI Young, SM Nehzati, S Benonisdottir, A Okbay… - Nature …, 2022 - nature.com
Abstract Effects estimated by genome-wide association studies (GWASs) include effects of
alleles in an individual on that individual (direct genetic effects), indirect genetic effects (for …

Modeling assortative mating and genetic similarities between partners, siblings, and in-laws

FA Torvik, EM Eilertsen, LJ Hannigan… - Nature …, 2022 - nature.com
Assortative mating on heritable traits can have implications for the genetic resemblance
between siblings and in-laws in succeeding generations. We studied polygenic scores and …

Within-sibship GWAS improve estimates of direct genetic effects

LJ Howe, MG Nivard, TT Morris, AF Hansen… - BioRxiv, 2021 - biorxiv.org
Estimates from genome-wide association studies (GWAS) represent a combination of the
effect of inherited genetic variation (direct effects), demography (population stratification …

Causal inference with genetic data: Past, present, and future

JB Pingault, R Richmond… - Cold Spring …, 2022 - perspectivesinmedicine.cshlp.org
The set of methods discussed in this collection has emerged from the convergence of two
scientific fields—genetics and causal inference. In this introduction, we discuss relevant …

The genetically informed neurobiology of addiction (GINA) model

R Bogdan, AS Hatoum, EC Johnson… - Nature Reviews …, 2023 - nature.com
Addictions are heritable and unfold dynamically across the lifespan. One prominent
neurobiological theory proposes that substance-induced changes in neural circuitry promote …

Maximizing the value of twin studies in health and behaviour

FA Hagenbeek, JS Hirzinger, S Breunig… - Nature Human …, 2023 - nature.com
In the classical twin design, researchers compare trait resemblance in cohorts of identical
and non-identical twins to understand how genetic and environmental factors correlate with …