Dexmedetomidine is an α 2-adrenoceptor agonist with sedative, anxiolytic, sympatholytic,
and analgesic-sparing effects, and minimal depression of respiratory function. It is potent …

Ischemia/reperfusion injury (IRI) is caused by a sudden temporary impairment of the blood
flow to the particular organ. IRI usually is associated with a robust inflammatory and …

Background Intestinal ischemia/reperfusion (I/R) injury has high morbidity and mortality
rates. Gut microbiota is a potential key factor affecting intestinal I/R injury. Populations …

Background Dexmedetomidine (DEX) is a highly selective alpha2 adrenoceptor agonist with
broad pharmacological effects, including sedation, analgesia, anxiolysis, and sympathetic …

Although there has been technical and pharmacological progress in kidney transplant
medicine, some patients may experience acute post-transplant complications. Among the …

Background—Cardiac surgery is associated with a high risk of cardiovascular and other
complications that translate into increased mortality and healthcare costs. This retrospective …

Dexmedetomidine (DEX) is a highly selective α2 adrenergic receptor (α2AR) agonist
currently used in clinical settings. Because DEX has dose‐dependent advantages of …

Acute kidney injury (AKI) is a common complication in critically ill patients and subsequently
worsens outcomes. Although many drugs to prevent and treat AKI have shown benefits in …

Sepsis is life-threatening and often leads to acute brain damage. Dexmedetomidine, an α2-
adrenoceptor agonist, has been reported to possess neuroprotective effects against various …

Optimal tissue oxygenation is essential for its normal function. Suboptimal oxygenation or
ischemia contributes to increased mortalities during various pathological conditions such as …