Tissue kallikreins are a family of fifteen secreted serine proteases encoded by the largest
protease gene cluster in the human genome. In the past decade, substantial progress has …

Trypsin and chymotrypsin-like serine proteases from family S1 (clan PA) constitute the
largest protease group in humans and more generally in vertebrates. The prototypes …

As the outermost layer of the skin, the epidermis is playing a major role in organism
homeostasis providing the first barrier against external aggressions. Although considered as …

Identifying the function of kallikrein-related peptidases (KLKs) in the epidermis has elicited
great interest over recent decades. KLKs comprise 15 serine proteases, and their activities …

Diabetic foot ulcers (DFU) are one of the major complications in type II diabetes patients and
can result in amputation and morbidity. Although multiple approaches are used clinically to …

Recent findings from the clinic and the laboratory have transformed the way proteases and
their inhibitors are perceived in the outermost layer of the skin, the epidermis. It now appears …

The entry of human papillomaviruses into host cells is a complex process. It involves
conformational changes at the cell surface, receptor switching, internalization by a novel …

Our understanding of the regulatory processes of reepithelialization during wound healing is
incomplete. In an attempt to map the genes involved in epidermal regeneration and …

Melatonin, a circadian rhythm–promoting molecule, has a variety of biological functions, but
the functional role of melatonin in the motility of mesenchymal stem cells (MSC s) has yet to …

The skin is a vital organ of the human body, serving numerous protective and functional
roles that are essential for survival. Residing in the epidermis are various epidermal …