MICAL-mediated oxidation of actin and its effects on cytoskeletal and cellular dynamics

S Rajan, JR Terman, E Reisler - Frontiers in Cell and Developmental …, 2023 - frontiersin.org
Actin and its dynamic structural remodelings are involved in multiple cellular functions,
including maintaining cell shape and integrity, cytokinesis, motility, navigation, and muscle …

Biochemically validated structural model of the 15‐subunit intraflagellar transport complex IFT‐B

NA Petriman, M Loureiro‐López, M Taschner… - The EMBO …, 2022 - embopress.org
Cilia are ubiquitous eukaryotic organelles impotant for cellular motility, signaling, and
sensory reception. Cilium formation requires intraflagellar transport of structural and …

Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome

MD Healy, KE McNally, R Butkovič, M Chilton, K Kato… - Cell, 2023 - cell.com
The Commander complex is required for endosomal recycling of diverse transmembrane
cargos and is mutated in Ritscher-Schinzel syndrome. It comprises two sub-assemblies …

The Neuron Navigators: Structure, function, and evolutionary history

RM Powers, RF Hevner, S Halpain - Frontiers in Molecular …, 2023 - frontiersin.org
Neuron navigators (Navigators) are cytoskeletal-associated proteins important for neuron
migration, neurite growth, and axon guidance, but they also function more widely in other …

Pathogenic SPTBN1 variants cause an autosomal dominant neurodevelopmental syndrome

MA Cousin, BA Creighton, KA Breau, RC Spillmann… - Nature …, 2021 - nature.com
SPTBN1 encodes βII-spectrin, the ubiquitously expressed β-spectrin that forms micrometer-
scale networks associated with plasma membranes. Mice deficient in neuronal βII-spectrin …

Calponin homology domain containing kinesin, KIS1, regulates chloroplast stromule formation and immunity

ND Meier, K Seward, JL Caplan… - Science Advances, 2023 - science.org
Chloroplast morphology changes during immunity, giving rise to tubule-like structures
known as stromules. Stromules extend along microtubules and anchor to actin filaments …

Molecular architecture of the human tRNA ligase complex

A Kroupova, F Ackle, I Asanović, S Weitzer… - Elife, 2021 - elifesciences.org
RtcB enzymes are RNA ligases that play essential roles in tRNA splicing, unfolded protein
response, and RNA repair. In metazoa, RtcB functions as part of a five-subunit tRNA ligase …

PDZ and LIM domain-encoding genes: their role in cancer development

X Jiang, Z Xu, S Jiang, H Wang, M Xiao, Y Shi, K Wang - Cancers, 2023 - mdpi.com
Simple Summary There are three subfamilies of human PDZ-LIM family proteins with a total
of 10 protein molecules, and PDZ-LIM family proteins serve as a class of scaffolding proteins …

Transgelins: cytoskeletal associated proteins implicated in the metastasis of colorectal cancer

J Liu, Y Zhang, Q Li, Y Wang - Frontiers in cell and developmental …, 2020 - frontiersin.org
Transgelins, including transgelin-1 (T-1), transgelin-2 (T-2), and transgelin-3 (T-3), are a
family of actin-binding proteins (ABPs) that can alter the structure and morphology of the …

Effects of Alternating Electric Field Assisted Freezing–Thawing–Aging Sequence on Data-Independent Acquisition Quantitative Proteomics of Longissimus dorsi …

G Wu, C Yang, HL Bruce, BC Roy, X Li… - Journal of Agricultural …, 2022 - ACS Publications
This study was designed to investigate the differences in the proteomes of bovine
Longissimus dorsi (LD) muscle during an alternating electric field (AEF)-assisted freezing …