[HTML][HTML] Multiple nano-drug delivery systems for intervertebral disc degeneration: Current status and future perspectives

W Liu, Z Ma, Y Wang, J Yang - Bioactive Materials, 2023 - Elsevier
Low back pain (LBP) is a common disease that imposes a huge social and economic
burden on people. Intervertebral disc (IVD) degeneration (IVDD) is often considered to be …

[HTML][HTML] MAPK/ERK signaling pathway: A potential target for the treatment of intervertebral disc degeneration

HJ Zhang, HY Liao, DY Bai, ZQ Wang… - Biomedicine & …, 2021 - Elsevier
Intervertebral disc degeneration (IDD) is a chronic skeletal muscle degenerative disease,
which is considered the main cause of low back pain. It seriously affects the quality of life of …

[HTML][HTML] A systematic review of the role of inflammatory biomarkers in acute, subacute and chronic non-specific low back pain

P Morris, K Ali, M Merritt, J Pelletier… - BMC musculoskeletal …, 2020 - Springer
Low back pain (LBP) is one of the greatest contributors to disability in the world and there is
growing interest on the role of biomarkers in LBP. To purpose of this review was to analyze …

MMPs and ADAMTSs in intervertebral disc degeneration

WJ Wang, XH Yu, C Wang, W Yang, WS He… - Clinica chimica acta, 2015 - Elsevier
Intervertebral disc degeneration (IDD) is the most common diagnosis in patients with low
back pain, a leading cause of musculoskeletal disability worldwide. The major components …

[HTML][HTML] Genetic factors in intervertebral disc degeneration

Y Feng, B Egan, J Wang - Genes & diseases, 2016 - Elsevier
Low back pain (LBP) is a major cause of disability and imposes huge economic burdens on
human society worldwide. Among many factors responsible for LBP, intervertebral disc …

[HTML][HTML] The PI3K/Akt pathway: a critical player in intervertebral disc degeneration

ZH Ouyang, WJ Wang, YG Yan, B Wang, GH Lv - Oncotarget, 2017 - ncbi.nlm.nih.gov
Intervertebral disc degeneration (IDD) is thought to be the primary cause of low back pain, a
severe public health problem worldwide. Current therapy for IDD aims to alleviate the …

[HTML][HTML] Degenerative disc disease of the spine: from anatomy to pathophysiology and radiological appearance, with morphological and functional considerations

L Scarcia, M Pileggi, A Camilli, A Romi… - Journal of Personalized …, 2022 - mdpi.com
Degenerative disc disease is a common manifestation in routine imaging of the spine; this
finding is partly attributable to physiological aging and partly to a pathological condition, and …

Osteoarthritis and intervertebral disc degeneration: Quite different, quite similar

CME Rustenburg, KS Emanuel, M Peeters… - JOR …, 2018 - Wiley Online Library
Intervertebral disc degeneration describes the vicious cycle of the deterioration of
intervertebral discs and can eventually result in degenerative disc disease (DDD), which is …

[HTML][HTML] Drug delivery in intervertebral disc degeneration and osteoarthritis: Selecting the optimal platform for the delivery of disease-modifying agents

F Colella, JP Garcia, M Sorbona, A Lolli… - Journal of controlled …, 2020 - Elsevier
Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) as major cause of chronic
low back pain represent the most common degenerative joint pathologies and are leading …

[HTML][HTML] Effects of tobacco smoking on the degeneration of the intervertebral disc: a finite element study

S Elmasry, S Asfour, JP de Rivero Vaccari… - PLoS One, 2015 - journals.plos.org
Tobacco smoking is associated with numerous pathological conditions. Compelling
experimental evidence associates smoking to the degeneration of the intervertebral disc …