Successful solid organ transplantation reflects meticulous attention to the details of
immunosuppression, balancing risks for graft rejection against risks for infection. The “net …

Despite ground‐breaking advances in allogeneic transplantation, allograft rejection and
immunosuppressant‐specific complications remain a major challenge in transplant …

Pulmonary fibrosis is a chronic and often fatal disease. The pathogenesis is characterized
by aberrant repair of lung parenchyma, resulting in loss of physiological homeostasis …

Under eubiotic conditions commensal microbes are known to provide a competitive barrier
against invading bacterial pathogens in the intestinal tract, on the skin or on the vaginal …

Chronic lung allograft dysfunction (CLAD) limits long-term survival after lung transplant (LT).
Ischemia–reperfusion injury (IRI) promotes chronic rejection (CR) and CLAD, but the …

Despite the widespread use of antibiotics, bacterial pneumonias in donors strongly
predispose to the fatal syndrome of primary graft dysfunction (PGD) following lung …

Advances in microbiome sequencing and wider availability of gnotobiotic facilities are
enabling mechanistic investigations into the commensal communities and pathways that …

The humanization of animals is a powerful tool for the exploration of human disease
pathogenesis in biomedical research, as well as for the development of therapeutic …

Background. Obliterative bronchiolitis (OB) remains the major complication limiting long-
term survival of patients after lung transplantation. We aimed to explore the effects of the …

The microbiome is an environmental factor in intricate symbiotic relationship with its hosts'
immune system, potentially shaping anticancer immunity, autoimmunity, and transplant …