Wilms tumour is the most common renal malignancy of childhood. The disease is curable in
the majority of cases, albeit at considerable cost in terms of late treatment-related effects in …

The primary causes of chronic kidney disease (CKD) in children differ from those of CKD in
adults. In the USA the most common diagnostic groups of renal disease that manifest before …

Aerobic glycolysis (the Warburg effect) facilitates tumor growth, and drugs targeting aerobic
glycolysis are being developed. However, how the Warburg effect is directly regulated is …

Congenital anomalies of the kidney and urinary tract (CAKUT) refer to a spectrum of
structural renal malformations and are the leading cause of end-stage renal disease in …

Congenital anomalies of the kidneys and urinary tracts (CAKUT) are disorders caused by
defects in the development of the kidneys and their outflow tracts. The formation of the …

Background Congenital anomalies of the kidney and urinary tract (CAKUT) are the most
prevalent cause of kidney disease in the first three decades of life. Previous gene panel …

Blastemal histology in chemotherapy-treated pediatric Wilms tumors (nephroblastoma) is
associated with adverse prognosis. To uncover the underlying tumor biology and find …

The neural crest (NC) is a transient, multipotent and migratory cell population that generates
an astonishingly diverse array of cell types during vertebrate development. These cells …

Mammalian kidney development has helped elucidate the general concepts of
mesenchymal-epithelial interactions, inductive signaling, epithelial cell polarization, and …

Knowledge of the primary cause of a disease is essential for elucidation of its mechanisms,
and for adequate classification, prognosis, and treatment. Recently, the causes of many …