A natural product chemist's guide to unlocking silent biosynthetic gene clusters

BC Covington, F Xu… - Annual review of …, 2021 - annualreviews.org
Microbial natural products have provided an important source of therapeutic leads and
motivated research and innovation in diverse scientific disciplines. In recent years, it has …

Microbe-driven chemical ecology: past, present and future

R Schmidt, D Ulanova, LY Wick, HB Bode… - The ISME …, 2019 - academic.oup.com
In recent years, research in the field of Microbial Ecology has revealed the tremendous
diversity and complexity of microbial communities across different ecosystems. Microbes …

Expanding the chemical diversity through microorganisms co-culture: Current status and outlook

D Arora, P Gupta, S Jaglan, C Roullier, O Grovel… - Biotechnology …, 2020 - Elsevier
Natural products (NPs) are considered as a cornerstone for the generation of bioactive leads
in drug discovery programs. However, one of the major limitations of NP drug discovery …

Discovery of novel secondary metabolites encoded in actinomycete genomes through coculture

JH Kim, N Lee, S Hwang, W Kim, Y Lee… - Journal of Industrial …, 2021 - academic.oup.com
Actinomycetes are a rich source of bioactive natural products important for novel drug leads.
Recent genome mining approaches have revealed an enormous number of secondary …

Targeted induction of a silent fungal gene cluster encoding the bacteria-specific germination inhibitor fumigermin

MC Stroe, T Netzker, K Scherlach, T Krüger… - Elife, 2020 - elifesciences.org
Microorganisms produce numerous secondary metabolites (SMs) with various biological
activities. Many of their encoding gene clusters are silent under standard laboratory …

Elicitation for activation of the actinomycete genome's cryptic secondary metabolite gene clusters

SS El-Hawary, MHA Hassan, AO Hudhud… - RSC …, 2023 - pubs.rsc.org
This review summarizes the recent advances in the elicitation approaches used to activate
the actinomycete genome's cryptic secondary metabolite gene clusters and shows the …

A bioprocess perspective on the production of secondary metabolites by Streptomyces in submerged co-cultures

T Boruta - World Journal of Microbiology and Biotechnology, 2021 - Springer
Filamentous microorganisms are potent sources of bioactive secondary metabolites, the
molecules formed in response to complex environmental signals. The chemical diversity …

How to completely squeeze a fungus—advanced genome mining tools for novel bioactive substances

A Schüller, L Studt-Reinhold, J Strauss - Pharmaceutics, 2022 - mdpi.com
Fungal species have the capability of producing an overwhelming diversity of bioactive
substances that can have beneficial but also detrimental effects on human health. These so …

Measurement techniques to resolve and control population dynamics of mixed-culture processes

I Schlembach, A Grünberger, MA Rosenbaum… - Trends in …, 2021 - cell.com
Microbial mixed cultures are gaining increasing attention as biotechnological production
systems, since they offer a large but untapped potential for future bioprocesses. Effects of …

Long-read metagenomics of marine microbes reveals diversely expressed secondary metabolites

R Huang, Y Wang, D Liu, S Wang, H Lv… - Microbiology …, 2023 - Am Soc Microbiol
Microbial secondary metabolites play crucial roles in microbial competition, communication,
resource acquisition, antibiotic production, and a variety of other biotechnological …