A natural product chemist's guide to unlocking silent biosynthetic gene clusters
BC Covington, F Xu… - Annual review of …, 2021 - annualreviews.org
Microbial natural products have provided an important source of therapeutic leads and
motivated research and innovation in diverse scientific disciplines. In recent years, it has …
motivated research and innovation in diverse scientific disciplines. In recent years, it has …
Microbe-driven chemical ecology: past, present and future
In recent years, research in the field of Microbial Ecology has revealed the tremendous
diversity and complexity of microbial communities across different ecosystems. Microbes …
diversity and complexity of microbial communities across different ecosystems. Microbes …
Expanding the chemical diversity through microorganisms co-culture: Current status and outlook
Natural products (NPs) are considered as a cornerstone for the generation of bioactive leads
in drug discovery programs. However, one of the major limitations of NP drug discovery …
in drug discovery programs. However, one of the major limitations of NP drug discovery …
Discovery of novel secondary metabolites encoded in actinomycete genomes through coculture
Actinomycetes are a rich source of bioactive natural products important for novel drug leads.
Recent genome mining approaches have revealed an enormous number of secondary …
Recent genome mining approaches have revealed an enormous number of secondary …
Targeted induction of a silent fungal gene cluster encoding the bacteria-specific germination inhibitor fumigermin
MC Stroe, T Netzker, K Scherlach, T Krüger… - Elife, 2020 - elifesciences.org
Microorganisms produce numerous secondary metabolites (SMs) with various biological
activities. Many of their encoding gene clusters are silent under standard laboratory …
activities. Many of their encoding gene clusters are silent under standard laboratory …
Elicitation for activation of the actinomycete genome's cryptic secondary metabolite gene clusters
This review summarizes the recent advances in the elicitation approaches used to activate
the actinomycete genome's cryptic secondary metabolite gene clusters and shows the …
the actinomycete genome's cryptic secondary metabolite gene clusters and shows the …
A bioprocess perspective on the production of secondary metabolites by Streptomyces in submerged co-cultures
T Boruta - World Journal of Microbiology and Biotechnology, 2021 - Springer
Filamentous microorganisms are potent sources of bioactive secondary metabolites, the
molecules formed in response to complex environmental signals. The chemical diversity …
molecules formed in response to complex environmental signals. The chemical diversity …
How to completely squeeze a fungus—advanced genome mining tools for novel bioactive substances
A Schüller, L Studt-Reinhold, J Strauss - Pharmaceutics, 2022 - mdpi.com
Fungal species have the capability of producing an overwhelming diversity of bioactive
substances that can have beneficial but also detrimental effects on human health. These so …
substances that can have beneficial but also detrimental effects on human health. These so …
Measurement techniques to resolve and control population dynamics of mixed-culture processes
Microbial mixed cultures are gaining increasing attention as biotechnological production
systems, since they offer a large but untapped potential for future bioprocesses. Effects of …
systems, since they offer a large but untapped potential for future bioprocesses. Effects of …
Long-read metagenomics of marine microbes reveals diversely expressed secondary metabolites
R Huang, Y Wang, D Liu, S Wang, H Lv… - Microbiology …, 2023 - Am Soc Microbiol
Microbial secondary metabolites play crucial roles in microbial competition, communication,
resource acquisition, antibiotic production, and a variety of other biotechnological …
resource acquisition, antibiotic production, and a variety of other biotechnological …