The epidermal growth factor receptor (EGFR) is a tyrosine kinase receptor of the ErbB family
that is abnormally activated in many epithelial tumors. Receptor activation leads to …

Abstract Learning Objectives After completing this course, the reader will be able to: Explain
the molecular biology of epidermal growth factor receptor (EGFR) function in malignant cells …

Multiple cellular pathways influence the growth and metastatic potential of tumors. This
creates heterogeneity, redundancy, and the potential for tumors to bypass signaling pathway …

Identification of the key roles of protein kinases in cancer has led to extensive efforts to
develop kinase inhibitors for the treatment of a wide range of cancers, and more than 30 …

Molecular targeting strategies for cancer therapy are distinct from conventional
chemotherapy and radiotherapy in their potential to provide increased tumor specificity. One …

Progress in identifying and understanding the molecular and cellular causes of cancer has
led to the discovery of anomalies that characterize cancer cells and that represent targets for …

Purpose To evaluate the efficacy and safety of the antiepidermal growth factor receptor
monoclonal antibody cetuximab in combination with platinum-based chemotherapy in …

Purpose: The epidermal growth factor receptor (EGFR) is a mediator of squamous cell
carcinoma of the head and neck (SCCHN) development. ZD1839 is an orally active …

Purpose This multicenter phase II study was undertaken to define the efficacy and safety of
cetuximab, an antiepidermal growth factor receptor chimeric human and murine monoclonal …

Purpose To evaluate efficacy and toxicity of cetuximab plus carboplatin in recurrent or
metastatic nasopharyngeal carcinoma (NPC) resistant to platinum treatment. Patients and …