Human Cytochrome P450 (CYP) enzymes constitute a superfamily of membrane-bound
hemoproteins that are responsible for the metabolism of a wide variety of clinically …

Many naturally occurring substances, traditionally used in popular medicines around the
world, contain the coumarin moiety. Coumarin represents a privileged scaffold for medicinal …

The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly
polymorphic human CYP2D6 gene locus. CYP2D6 genetic variation impacts the metabolism …

Ferroptosis is a form of regulated cell death that is intricately linked to cellular metabolism. In
the forefront of research on ferroptosis, the peroxidation of polyunsaturated fatty acids has …

Enzymatically oxidized lipids are a specific group of biomolecules that function as key
signaling mediators and hormones, regulating various cellular and physiological processes …

Mitochondria are essential sites for steroid hormone biosynthesis. Mitochondria in the
steroidogenic cells of the adrenal, gonad, placenta and brain contain the cholesterol side …

The basic-helix/loop/helix per-Arnt-sim (bHLH/PAS) family comprises many transcription
factors, found throughout all three kingdoms of life; bHLH/PAS members “sense” …

Eupatorin has been reported with in vitro cytotoxic effect on several human cancer cells.
However, reports on the mode of action and detail mechanism of eupatorin in vitro in breast …

Numerous benefits have been attributed to dietary long-chain omega-3 polyunsaturated fatty
acids (n-3 LC-PUFAs), including protection against cardiac arrhythmia, triglyceride-lowering …

The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor regulating
adaptive and maladaptive responses toward exogenous and endogenous signals …