Oral submucous fibrosis: etiological mechanism, malignant transformation, therapeutic approaches and targets

X Qin, Y Ning, L Zhou, Y Zhu - International journal of molecular sciences, 2023 - mdpi.com
Oral submucosal fibrosis (OSF) is a chronic, progressive and potentially malignant oral
disorder with a high regional incidence and malignant rate. With the development of the …

[HTML][HTML] Genetic and epigenetic instability induced by betel quid associated chemicals

RB Muthukumaran, P Bhattacharjee, P Bhowmick… - Toxicology reports, 2023 - Elsevier
Over the years, betel quid chewing and tobacco use have attracted considerable interest as
they are implicated as the most likely causative risk factors of oral and esophageal cancers …

Metabolomic profile of Indonesian betel quids

P Zhang, EF Sari, MJ McCullough, N Cirillo - Biomolecules, 2022 - mdpi.com
Consumption of areca nut alone, or in the form of betel quid (BQ), has negative health effects
and is carcinogenic to humans. Indonesia is one of the largest producers of areca nuts …

Comparative analysis of two arecoline‐induced oral submucous fibrosis models

S Tang, L Jiang, Y Zhou, T Zhou, Y Peng… - Oral …, 2023 - Wiley Online Library
Objective The limited understanding of the molecular mechanism for oral submucosal
fibrosis (OSF) poses challenges to the development of effective prevention and treatment …

[HTML][HTML] Areca nut-induced oral fibrosis–Reassessing the biology of oral submucous fibrosis

M Sharma, SC Sarode, G Sarode… - Journal of Oral …, 2024 - Elsevier
Background Oral submucous fibrosis (OSF) is a pathological condition characterized by
excessive tissue healing resulting from physical, chemical, or mechanical trauma. Notably …

Determination and quality evaluation of active ingredients in areca nut using near-infrared rapid detection technology

J Dai, W Tang, J Zhang, X Kang, W Dai, J Ji… - Microchemical …, 2024 - Elsevier
Areca is a significant cash crop used in both traditional Chinese medicine and various foods
because of its numerous pharmacological benefits and the stimulation it offers. Great …

Precursor Lesions, Overdiagnosis, and Oral Cancer: A Critical Review

N Cirillo - Cancers, 2024 - mdpi.com
Simple Summary This article discusses a common approach to the early detection of oral
cancer, which focuses on identifying and monitoring certain mouth conditions, known as oral …

Plant leads for mitigation of oral submucous fibrosis: Current scenario and future prospect

S Pal, D Sharma, NP Yadav - Oral Diseases, 2024 - Wiley Online Library
The aim of this review is to enumerate medicinal plants and their bioactive compounds that
may become potential leads in the mitigation of oral submucous fibrosis (OSMF) in the …

A Critical Interpretive Synthesis of the Role of Arecoline in Oral Carcinogenesis: Is the Local Cholinergic Axis a Missing Link in Disease Pathophysiology?

H Gocol, JH Zeng, S Chang, BY Koh, H Nguyen… - Pharmaceuticals, 2023 - mdpi.com
Arecoline is the primary active carcinogen found in areca nut and has been implicated in the
pathogenesis of oral squamous cell carcinoma (OSCC) and oral submucous fibrosis (OSF) …

Alteration of salivary LPO, MDA, LDH, glutathione, GPx, SOD and vitamins in oral submucous fibrosis: A three-level meta-analysis study

MDC Surboyo, RM Boedi, FY Mahdani… - Clinical …, 2024 - Elsevier
This study aims to investigate the alteration of salivary biomarker profiling in the
development of oral submucous fibrosis (OSMF) and to explore the influence of saliva in the …