Resistance to natural and synthetic gene drive systems
Scientists are rapidly developing synthetic gene drive elements intended for release into
natural populations. These are intended to control or eradicate disease vectors and pests, or …
natural populations. These are intended to control or eradicate disease vectors and pests, or …
Gene drive: progress and prospects
Gene drive is a naturally occurring phenomenon in which selfish genetic elements
manipulate gametogenesis and reproduction to increase their own transmission to the next …
manipulate gametogenesis and reproduction to increase their own transmission to the next …
Impacts of sex ratio meiotic drive on genome structure and function in a stalk-eyed fly
Stalk-eyed flies in the genus Teleopsis carry selfish genetic elements that induce sex ratio
(SR) meiotic drive and impact the fitness of male and female carriers. Here, we assemble …
(SR) meiotic drive and impact the fitness of male and female carriers. Here, we assemble …
Adequacy and sufficiency evaluation of existing EFSA guidelines for the molecular characterisation, environmental risk assessment and post‐market environmental …
EFSA Panel on Genetically Modified Organisms … - Efsa …, 2020 - Wiley Online Library
Advances in molecular and synthetic biology are enabling the engineering of gene drives in
insects for disease vector/pest control. Engineered gene drives (that bias their own …
insects for disease vector/pest control. Engineered gene drives (that bias their own …
X chromosome drive is constrained by sexual selection and influences ornament evolution
KA Paczolt, GT Welsh… - Proceedings of the …, 2023 - royalsocietypublishing.org
Experimental evolution provides an integrative method for revealing complex interactions
among evolutionary processes. One such interaction involves sex-linked selfish genetic …
among evolutionary processes. One such interaction involves sex-linked selfish genetic …
Meiotic drive adaptive testes enlargement during early development in the stalk-eyed fly
SL Bradshaw, L Meade… - Biology …, 2022 - royalsocietypublishing.org
The sex ratio (SR) X-linked meiotic drive system in stalk-eyed flies destroys Y-bearing
sperm. Unlike other SR systems, drive males do not suffer fertility loss. They have greatly …
sperm. Unlike other SR systems, drive males do not suffer fertility loss. They have greatly …
Ancient gene drives: an evolutionary paradox
TAR Price, R Verspoor… - Proceedings of the …, 2019 - royalsocietypublishing.org
Selfish genetic elements such as selfish chromosomes increase their transmission rate
relative to the rest of the genome and can generate substantial cost to the organisms that …
relative to the rest of the genome and can generate substantial cost to the organisms that …
Fitness consequences of a non-recombining sex-ratio drive chromosome can explain its prevalence in the wild
Understanding the pleiotropic consequences of gene drive systems on host fitness is
essential to predict their spread through a host population. Here, we study sex-ratio (SR) X …
essential to predict their spread through a host population. Here, we study sex-ratio (SR) X …
Maintenance of fertility in the face of meiotic drive
L Meade, SR Finnegan, R Kad, K Fowler… - The American …, 2020 - journals.uchicago.edu
Selfish genetic elements that gain a transmission advantage through the destruction of
sperm have grave implications for drive male fertility. In the X-linked meiotic drive system …
sperm have grave implications for drive male fertility. In the X-linked meiotic drive system …
An X-linked meiotic drive allele has strong, recessive fitness costs in female Drosophila pseudoobscura
Selfish 'meiotic drive'alleles are transmitted to more than 50% of offspring, allowing them to
rapidly invade populations even if they reduce the fitness of individuals carrying them …
rapidly invade populations even if they reduce the fitness of individuals carrying them …