Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer's disease
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …

Neuroinflammation is a hallmark of many neurodegenerative diseases (NDs) and plays a
fundamental role in mediating the onset and progression of disease. Microglia, which …

Altered microglial states affect neuroinflammation, neurodegeneration, and disease but
remain poorly understood. Here, we report 194,000 single-nucleus microglial transcriptomes …

Alzheimer's disease (AD) is an age-related disease pathologically defined by the deposition
of amyloid plaques and neurofibrillary tangles in the brain parenchyma. Single-cell profiling …

We developed an endophenotype disease module-based methodology for Alzheimer's
disease (AD) drug repurposing and identified sildenafil as a potential disease risk modifier …

Alzheimer's disease (AD) remains one of the grand challenges facing human society. Much
controversy exists around the complex and multifaceted pathogenesis of this prevalent …

Microglia are central players in brain innate immunity and have been the subject of
extensive research in Alzheimer's disease (AD). In this review, we aim to summarize the …

Alzheimer's disease (AD) pathologies were discovered in the accessible neurosensory
retina. However, their exact nature and topographical distribution, particularly in the early …

Alzheimer's disease (AD) is defined as a severe chronic degenerative neurological disease
in human. The pathogenic mechanism of AD has been convincingly elucidated by the …

SARS-CoV-2 infection causes COVID-19. Several clinical reports have linked COVID-19
during pregnancy to negative birth outcomes and placentitis. However, the …