Ventral tegmental area: cellular heterogeneity, connectivity and behaviour

M Morales, EB Margolis - Nature Reviews Neuroscience, 2017 - nature.com
Dopamine-releasing neurons of the ventral tegmental area (VTA) have central roles in
reward-related and goal-directed behaviours. VTA dopamine-releasing neurons are …

[HTML][HTML] Therapeutic potential of targeting G protein-gated inwardly rectifying potassium (GIRK) channels in the central nervous system

D Jeremic, I Sanchez-Rodriguez… - Pharmacology & …, 2021 - Elsevier
G protein-gated inwardly rectifying potassium channels (Kir3/GirK) are important for
maintaining resting membrane potential, cell excitability and inhibitory neurotransmission …

Neuronal G protein-gated K+ channels

H Luo… - American Journal of …, 2022 - journals.physiology.org
G protein-gated inwardly rectifying K+ (GIRK/Kir3) channels exert a critical inhibitory
influence on neurons. Neuronal GIRK channels mediate the G protein-dependent …

Multiplexed neurochemical signaling by neurons of the ventral tegmental area

DJ Barker, DH Root, S Zhang, M Morales - Journal of chemical …, 2016 - Elsevier
The ventral tegmental area (VTA) is an evolutionarily conserved structure that has roles in
reward-seeking, safety-seeking, learning, motivation, and neuropsychiatric disorders such …

Endogenous opiates and behavior: 2016

RJ Bodnar - Peptides, 2018 - Elsevier
This paper is the thirty-ninth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2016 …

Kir channel molecular physiology, pharmacology, and therapeutic implications

M Cui, L Cantwell, A Zorn, DE Logothetis - Pharmacology of Potassium …, 2021 - Springer
For the past two decades several scholarly reviews have appeared on the inwardly rectifying
potassium (Kir) channels. We would like to highlight two efforts in particular, which have …

Hippocampal long‐term synaptic depression and memory deficits induced in early amyloidopathy are prevented by enhancing G‐protein‐gated inwardly rectifying …

I Sánchez‐Rodríguez, S Djebari… - Journal of …, 2020 - Wiley Online Library
Hippocampal synaptic plasticity disruption by amyloid‐β (Aβ) peptides+ thought to be
responsible for learning and memory impairments in Alzheimer's disease (AD) early stage …

Opioid-induced rewards, locomotion, and dopamine activation: A proposed model for control by mesopontine and rostromedial tegmental neurons

S Steidl, DI Wasserman, CD Blaha… - … & Biobehavioral Reviews, 2017 - Elsevier
Opioids, such as morphine or heroin, increase forebrain dopamine (DA) release and
locomotion, and support the acquisition of conditioned place preference (CPP) or self …

Next-generation inward rectifier potassium channel modulators: discovery and molecular pharmacology

CD Weaver, JS Denton - American Journal of Physiology …, 2021 - journals.physiology.org
Inward rectifying potassium (Kir) channels play important roles in both excitable and
nonexcitable cells of various organ systems and could represent valuable new drug targets …

[HTML][HTML] Complexes of ghrelin GHS-R1a, GHS-R1b, and dopamine D1 receptors localized in the ventral tegmental area as main mediators of the dopaminergic effects …

G Navarro, W Rea, C Quiroz, E Moreno… - Journal of …, 2022 - Soc Neuroscience
Ghrelin receptor, also known as growth hormone secretagogue receptor (GHS-R1a), is
coexpressed with its truncated isoform GHS-R1b, which does not bind ghrelin or signal, but …