Small G proteins play a central role in the organization of the secretory and endocytic
pathways. The majority of such small G proteins are members of the Rab family, which are …

Typical members of the Ras superfamily of small monomeric GTP-binding proteins function
as regulators of diverse processes by cycling between biologically active GTP-and inactive …

Fragile X syndrome, the most common form of inherited mental retardation and leading
genetic cause of autism, is caused by transcriptional silencing of the Fmr1 gene. The fragile …

▪ Abstract The existence and function of actin in the nucleus has been hotly debated for forty
years. Recently, β-actin was found to be a component of mammalian SWI/SNF-like BAF …

During the past twenty years, evidence has accumulated for the presence of phospholipids
within the nuclei of eukaryotic cells. These phospholipids are distinct from those that are …

Fragile X syndrome (FXS) is an inherited neurologic disease caused by loss of fragile X
mental retardation protein (FMRP), which is hypothesized to mediate negative regulation of …

Phosphoinositide 3 kinase enhancer (PIKE) is a recently identified nuclear GTPase that
activates nuclear phosphoinositide 3-kinase (PI3 kinase). We have identified, cloned and …

We present a novel method for the identification of sets of mutually exclusive gene
alterations in a given set of genomic profiles. We scan the groups of genes with a common …

Epidermal growth factor receptor (EGFR) overexpression occurs in nearly 50% of cases of
glioblastoma (GBM), but its clinical and biological implications are not well understood. We …

Abstract Toll-like receptor 4 (TLR4) initiates both myeloid differentiation factor 88 (MyD88)-
dependent and Toll/interleukin (IL)-1R domain–containing adapter, inducing interferon (IFN) …