Mutation is the source of all heritable diversity, the essential material of evolution and
breeding. While mutation rates are often regarded as constant, variability in mutation rates …

Five versions of the Chlamydomonas reinhardtii reference genome have been produced
over the last two decades. Here we present version 6, bringing significant advances in …

HUH endonucleases of the Rep (replication protein) class mediate the replication of highly
diverse plasmids and viral genomes across all domains of life. HUH transposases have …

Telomeres and subtelomeres, the genomic regions located at chromosome extremities, are
essential for genome stability in eukaryotes. In the absence of the canonical maintenance …

Transposable elements (TEs) are selfish genetic elements whose antagonistic interactions
with hosts represent a common genetic conflict in eukaryotes. To resolve this conflict, hosts …

Recent advances in long-read sequencing technologies have enabled the complete
assembly of eukaryotic genomes from telomere to telomere by allowing repeated regions to …

Mutation is the ultimate source of genetic variation, the bedrock of evolution. Yet, predicting
the consequences of new mutations remains a challenge in biology. Gene expression …

Sequencing an “entire” genome used to be an accomplishment. However, improvements in
sequencing technologies have resulted in an avalanche of genomes “in progress”; good …

Chlamydomonas has become a premier model organism thanks to the ease with which
gene function can be analyzed experimentally. With the advent of genome and …

Latency is a common strategy in a wide range of viral lineages, but its prevalence in giant
viruses remains unknown. Here we describe the activity and viral production from a 617 kbp …